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GlossaryAMP-activated protein kinase (AMPK)

regulates cellular energy by activating ATP-producing pathways

AMP-activated protein kinase (AMPK) is an enzyme that plays a crucial role in cellular energy regulation. It acts as a cellular energy sensor, activating pathways that generate ATP (the cell's energy currency) when energy levels are low and inhibiting processes that consume ATP when energy is abundant. This helps maintain energy balance within cells and is important for overall metabolic health.

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research Modulating Aging and Aging-Related Symptoms Using Endogenous Small Molecules

January 2019

A molecule called α-ketobutyrate was found to extend lifespan and improve aging-related symptoms in worms and mice by activating certain cellular pathways and may help develop anti-aging treatments for humans.

Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

research Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

1 citations , May 2022 in “Frontiers in Pharmacology”

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

research A Review of Metabolic Dysregulation in Lymphocytic Cicatricial Alopecia: Exploring the Connections and Therapeutic Implications

1 citations , March 2025 in “Journal of Investigative Dermatology”

Metabolic issues may trigger lymphocytic cicatricial alopecia, and treatments targeting these issues could help.

research Stem Cell Rejuvenation and the Role of Autophagy in Age Retardation by Caloric Restriction: An Update

19 citations , July 2018 in “Mechanisms of Ageing and Development”

Eating less can slow aging and help keep stem cells healthy by cleaning out damaged cell parts.

research Folliculin Encoded by the BHD Gene Interacts with a Binding Protein, FNIP1, and AMPK, and Is Involved in AMPK and mTOR Signaling

475 citations , October 2006 in “Proceedings of the National Academy of Sciences”

Folliculin helps regulate energy and nutrient sensing, impacting Birt–Hogg–Dubé syndrome.

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community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 2 years ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Topical Metformin for Hair Transplant donor area skin/hair regeneration?

in Research/Science 3 upvotes 11 months ago

Topical Metformin shows potential for regenerating hair follicles and minimizing scarring in hair transplant donor areas, similar to Verteporfin but without its side effects. The discussion suggests considering Metformin for post-hair transplant care, though more human trials are needed.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Dutasteride Users, do you Still Take Creatine?

in Finasteride/Dutasteride 11 upvotes 8 months ago

The conversation discusses the potential impact of creatine on hair loss, with some users sharing personal experiences of increased shedding while others argue there's no scientific evidence linking creatine to hair loss. The original poster switched from finasteride to dutasteride and is considering resuming creatine after monitoring its effects on hair loss.

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