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GlossaryAMP-activated protein kinase (AMPK)

regulates cellular energy by activating ATP-producing pathways

AMP-activated protein kinase (AMPK) is an enzyme that plays a crucial role in cellular energy regulation. It acts as a cellular energy sensor, activating pathways that generate ATP (the cell's energy currency) when energy levels are low and inhibiting processes that consume ATP when energy is abundant. This helps maintain energy balance within cells and is important for overall metabolic health.

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research Sesn2/AMPK/mTOR Signaling Mediates Balance Between Survival and Apoptosis in Sensory Hair Cells Under Stress

21 citations, October 2017 in “Cell death and disease”

Sesn2 protects inner ear hair cells from damage by regulating certain cell survival pathways.

research Transient Calcium Entry by Plasmalogen-Mediated Activation of Receptor Potential Cation Channel Promotes AMPK Activity

3 citations, November 2022 in “Frontiers in molecular biosciences”

Plasmalogens activate a channel in cells that may stimulate hair growth.

research Metformin, an Activator of AMPK, Promotes the Growth of Hair Follicles via the AMPK/β-Catenin Signaling Pathway

May 2019 in “Journal of Clinical Dermatology”

Metformin helps hair growth by affecting cell signals related to hair follicle development.

research Cepharanthine: An Update of Its Mode of Action, Pharmacological Properties, and Medical Applications

125 citations, May 2019 in “Phytomedicine”

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

research Birt-Hogg-Dubé Syndrome: From Gene Discovery to Molecularly Targeted Therapies

39 citations, October 2012 in “Familial cancer”

New therapies for Birt–Hogg–Dubé syndrome are being developed based on understanding the FLCN gene's role.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Fats on your Head to Stop Hair Loss?

in Research/Science 142 upvotes 10 months ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 743 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.