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GlossaryInflammasome

complex of proteins detecting harmful stimuli, triggering inflammation

An inflammasome is a complex of proteins within cells that plays a crucial role in the immune system by detecting harmful stimuli, such as pathogens or stress signals. When activated, it triggers an inflammatory response by promoting the release of pro-inflammatory cytokines, which help to fight infections but can also contribute to inflammatory diseases if not properly regulated.

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research Cell Death in Skin Function, Inflammation, and Disease

12 citations, August 2022 in “Biochemical Journal”

Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.

research Hidradenitis Suppurativa: A Folliculotropic Disease of Innate Immune Barrier Dysfunction?

9 citations, August 2021 in “Experimental dermatology”

Hidradenitis suppurativa is a skin disease caused by the breakdown of the skin's natural immune barriers, especially around hair follicles.

research Aberrant Inflammasome Activation as a Driving Force of Human Autoimmune Skin Disease

3 citations, May 2023 in “Frontiers in immunology”

Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.

research Co-Editors' Messages

March 2013 in “Hair transplant forum international”

Inflammation linked to the immune response may play a role in causing various types of hair loss.

Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

research Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

22 citations, March 2017 in “Scientific reports”

Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.

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