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GlossaryAIM2 inflammasome

protein complex detecting foreign DNA, triggering immune responses

The AIM2 inflammasome is a protein complex in the immune system that detects foreign DNA inside cells, such as from viruses or bacteria. When AIM2 senses this DNA, it activates a series of responses that lead to inflammation and the destruction of the infected cell, helping to protect the body from infections.

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research Aberrant Inflammasome Activation as a Driving Force of Human Autoimmune Skin Disease

3 citations, May 2023 in “Frontiers in immunology”

Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.

Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

research Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

22 citations, March 2017 in “Scientific reports”

Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.

research Inflammasome Proteins as Biomarkers of Injury and Disease

January 2014 in “Springer eBooks”

Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.

research Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing

13 citations, February 2023 in “Aging”

A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.

research The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice

59 citations, September 2015 in “Journal of Immunology”

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

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