TLDR Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.
The document from 2014 explores the significance of inflammasome proteins as biomarkers for various injuries and diseases due to their role in the immune response. It highlights that elevated levels of these proteins, such as caspase-1, NLRP1, NLRP3, and ASC, are associated with poor outcomes in conditions like traumatic brain injury, multiple sclerosis, and type II diabetes mellitus, where they can indicate disease progression or predict treatment response. In the context of androgenetic alopecia, higher levels of caspase-1 in hair follicles are linked to a lack of response to finasteride treatment. The document also notes the involvement of inflammasomes in atherosclerosis, inflammatory bowel disease, and male infertility post-spinal cord injury, suggesting their potential as diagnostic and prognostic tools due to their accessibility in tissue fluids and exosomes.
185 citations,
March 2011 in “The Journal of Sexual Medicine” Finasteride for hair loss can cause long-lasting sexual side effects like low libido and erectile dysfunction.
52 citations,
June 2009 in “Current Opinion in Endocrinology, Diabetes and Obesity” The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.
3 citations,
May 2023 in “Frontiers in immunology” Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.
12 citations,
August 2022 in “Biochemical Journal” Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.
22 citations,
March 2017 in “Scientific reports” Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.
1 citations,
April 2016 in “Journal of Investigative Dermatology” NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.
1 citations,
April 2016 in “Journal of Investigative Dermatology” UV photography can help identify people at higher risk for skin cancer, and male pattern baldness at age 45 is linked to a higher risk of certain skin cancers.
