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GlossaryInflammasome Activation

process triggering immune response to harmful stimuli

Inflammasome activation refers to the process by which a group of proteins in the immune system, called inflammasomes, detect harmful stimuli like infections or cellular damage and trigger an inflammatory response. This activation leads to the production of molecules like cytokines that help fight off infections but can also contribute to inflammatory diseases if not properly regulated.

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research Characterization of Novel TMEM173 Mutation with Additive IFIH1 Risk Allele

1 citations , August 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

A new mutation in the TMEM173 gene and a risk allele in IFIH1 cause a unique set of immune-related symptoms.

The Possible Role of PTEN-Induced Kinase 1-Mediated Mitophagy in Regulating Inflammasome Activation in the Pathogenesis of Alopecia Areata

research The Possible Role of PTEN-Induced Kinase 1-Mediated Mitophagy in Regulating Inflammasome Activation in the Pathogenesis of Alopecia Areata

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Activating mitophagy may help manage a key immune response involved in the hair loss condition alopecia areata.

research Uncovering the Role of UV Exposure History and Genetics in Determining Skin Sun Damage

1 citations , April 2016 in “Journal of Investigative Dermatology”

UV photography can help identify people at higher risk for skin cancer, and male pattern baldness at age 45 is linked to a higher risk of certain skin cancers.

research NLRP1 Promotes Tumor Growth by Enhancing Inflammasome Activation and Suppressing Caspase-3 Activity in Human Melanoma

1 citations , April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

research Genotoxic Agents: An Unexpected Effect on Healthy Epithelia

2 citations , December 2020 in “Developmental cell”

Chemotherapy drugs can cause abnormal growth and changes in healthy skin and gland cells.

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