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    Glossary Inflammasome Activation

    process triggering immune response to harmful stimuli

    Inflammasome activation refers to the process by which a group of proteins in the immune system, called inflammasomes, detect harmful stimuli like infections or cellular damage and trigger an inflammatory response. This activation leads to the production of molecules like cytokines that help fight off infections but can also contribute to inflammatory diseases if not properly regulated.

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    Research 30 of 589

    1. Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles Scientific reports · 2017 · 22 citations
    2. 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma Journal of Investigative Dermatology · 2016 · 1 citations
    3. 1330 The possible role of PTEN-induced kinase 1-mediated mitophagy by regulating inflammasome activation in the pathogenesis of alopecia areata 2023
    4. Baricitinib Attenuates IFN-γ and Polyinosinic:polycytidylic Acid‒Induced Mitochondrial Damage and Inflammasome Activation in Human Keratinocytes Journal of Investigative Dermatology · 2022
    5. Aberrant inflammasome activation as a driving force of human autoimmune skin disease Frontiers in immunology · 2023 · 3 citations
    6. 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis Journal of Investigative Dermatology · 2023
    7. NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium Cell Communication and Signaling · 2019 · 50 citations
    8. Smart Fluids As Autophagy-Activating Photoprotectors: In Vitro Analysis of Dead Sea Water and Magnetized Saline Water Against Ultraviolet B (UVB)-Induced Photodamage in Human Keratinocytes Cureus · 2025 · 1 citations
    9. Novel TMEM173 Mutation and the Role of Disease Modifying Alleles Frontiers in immunology · 2019 · 47 citations
    10. Genotoxic Agents: An Unexpected Effect on Healthy Epithelia Developmental cell · 2020 · 2 citations
    11. Characterization of novel TMEM173 mutation with additive IFIH1 risk allele bioRxiv (Cold Spring Harbor Laboratory) · 2018 · 1 citations
    12. 642 Uncovering the role of UV exposure history and genetics in determining skin sun damage Journal of Investigative Dermatology · 2016 · 1 citations
    13. 646 SOX4 is essential for melanoma tumorigenesis Journal of Investigative Dermatology · 2016
    14. The crosstalk between PTEN ‐induced kinase 1‐mediated mitophagy and the inflammasome in the pathogenesis of alopecia areata Experimental Dermatology · 2023 · 6 citations
    15. Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions The Journal of Cell Biology · 2024 · 4 citations
    16. Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation Experimental Dermatology · 2019 · 51 citations
    17. The many faces of interleukin-17 in inflammatory skin diseases 2016 · 77 citations
    18. Inflammation in androgenetic alopecia and hair loss: linking neurosciences-endocrinology-dermatology Hair transplant forum international · 2012 · 1 citations
    19. Hair follicle mesenchymal stem cell exosomal lncRNA H19 inhibited NLRP3 pyroptosis to promote diabetic mouse skin wound healing Aging · 2023 · 13 citations
    20. Fermented Yeast Complex Extract Promotes Hair Regrowth by Decreasing Oxidative Stress Antioxidants · 2025
    21. Acne-Associated Syndromes Springer eBooks · 2019
    22. Inflammasome Proteins as Biomarkers of Injury and Disease Springer eBooks · 2014
    23. Oral administration of berberine represses macrophage activation-associated benign prostatic hyperplasia: a pivotal involvement of the NF-κB Aging · 2021 · 8 citations
    24. The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice Journal of Immunology · 2015 · 59 citations
    25. Inflammasome Proteins Are Reliable Biomarkers of the Inflammatory Response in Aneurysmal Subarachnoid Hemorrhage Cells · 2024 · 4 citations
    26. What “regenerative” means in aesthetic medicine: a narrative literature review attempting to demystify the core essence of regenerative aesthetics Plastic and Aesthetic Research · 2026
    27. Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils 2020 · 16 citations
    28. Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology American Journal of Clinical Dermatology · 2026
    29. Viewpoint 3 Experimental dermatology · 2008
    30. Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair Burns & Trauma · 2026