Genotoxic Agents: An Unexpected Effect on Healthy Epithelia

December 2020 in “ Developmental cell ”

Michael Cangkrama, Sabine Werner

DNA cross-linking agents hyperplasia stem cell fate mis-specification epithelial tissues skin hair follicles inflammasome activation IL-1β dermal fibroblasts keratinocytes hyperproliferation fibroblasts

Studysummary In this study, DNA cross-linking agents used in cancer therapy were found to cause unintended hyperplasia and fate mis-specification in normal epithelial stem cells through inflammasome activation in dermal fibroblasts.

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research Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

403 citations , December 2018 in “Cell stem cell”

This study suggests that phenotypic plasticity, including processes like dedifferentiation and transdifferentiation, plays a crucial role in cancer initiation, progression, and therapy resistance, broadening our understanding of cancer dynamics and potential treatment strategies.