1 citations
,
July 2021 in “Clinical and Experimental Dermatology” This study suggests that finasteride is a safe and effective alternative therapy for women with hidradenitis suppurativa who have contraindications or intolerance to spironolactone.
56 citations
,
October 2018 in “Journal of The American Academy of Dermatology” This review discusses the role of androgens in women's skin-related conditions like acne, hirsutism, and female pattern hair loss, noting the lack of dermatology guidelines for when to pursue endocrinologic evaluation.
48 citations
,
July 2018 in “Journal of The American Academy of Dermatology” This study observed that treatment with spironolactone significantly improved pain, inflammatory lesion count, and HS-PGA scores among female patients with hidradenitis suppurativa, suggesting its potential as an effective treatment option, even at lower doses, despite no change in Hurley stage or fistula count.
100 citations
,
September 2017 in “Molecular and Cellular Endocrinology” This review discusses the molecular mechanisms of androgens and androgen receptors in skin disorders, particularly androgenetic alopecia, and reports no new clinical results; it highlights potential areas for future treatment development.
86 citations
,
June 2017 in “Anais Brasileiros de Dermatologia” This review discusses the role of antioxidants in managing oxidative skin damage and reports no new results, emphasizing the need for understanding their mechanisms, limitations, and risks for safe use.
74 citations
,
October 2015 in “Experimental Dermatology” This study found that mTOR gene expression was significantly increased and S6K1 activation was observed in skin samples from acne patients compared to healthy controls, suggesting mTORC1's involvement in acne pathogenesis.
71 citations
,
January 2015 in “The Scientific World Journal” This review discusses the link between insulin resistance and skin conditions such as acanthosis nigricans and psoriasis, but provides no new clinical results.
51 citations
,
February 2013 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This review examines evidence on metformin's use in treating various skin disorders and discusses associated cutaneous side-effects; it reports no new clinical results.
124 citations
,
July 2012 in “Archives of Dermatological Research” This review discusses the roles of androgens and androgen receptors in skin-related disorders and suggests that targeting androgen receptors may be a more effective treatment strategy.
200 citations
,
August 2009 in “Experimental dermatology” This article reviews the role of IGF-1 in acne pathogenesis and discusses how diet and smoking may influence insulin/IGF-1 signaling, but reports no new clinical results.
463 citations
,
September 2004 in “Clinics in dermatology” This review discusses the development, function, and complex roles of sebaceous glands in acne and suggests future acne treatments should target inflammation and lipid production; it reports no new clinical results.
