Hidradenitis Suppurativa Lesions Are Associated With Decreased Collagen, Decreased Elastin, And Increased Neovascularization

The study on hidradenitis suppurativa (HS) analyzed 104 lesions and found that the condition was characterized by ruptured hair follicles leading to a significant chronic inflammatory response. Histological examination revealed common features such as migrating epithelial sheets, acute and chronic inflammation, and granulation tissue. Notably, areas with chronic inflammation showed a significant decrease in collagen and elastin, alongside increased neovascularization. These findings suggested that HS lesions were associated with structural changes in the skin's connective tissue and blood vessels.