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GlossaryKrebs cycle (TCA cycle)

series of reactions in mitochondria generating cellular energy

The Krebs cycle, also known as the Citric Acid Cycle or TCA cycle, is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. This cycle takes place in the mitochondria and produces ATP, NADH, and FADH2, which are essential for cellular energy and metabolism.

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Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

research Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking a key energy pathway in human hair follicles can trigger stress responses that stop cell growth.

research Glucose and Acetate Metabolism by Isolated Sheep Wool Follicles

8 citations , April 1965 in “Archives of biochemistry and biophysics”

Sheep wool follicles can metabolize both glucose and acetate using different pathways important for wool growth.

research Defining Metabolic Flexibility in Hair Follicle Stem Cell Induced Squamous Cell Carcinoma

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Blocking both main energy pathways can stop hair follicle stem cell-induced skin cancer growth.

research Elevated Carbon Dioxide Levels Lead to Proteome-Wide Alterations for Optimal Growth of a Fast-Growing Cyanobacterium, Synechococcus Elongatus PCC 11801

45 citations , April 2019 in “Scientific Reports”

Higher CO2 levels help a cyanobacterium grow better by boosting photosynthesis and carbon uptake.

research Differential Metabolic Adaptations Define Responses of Winner and Loser Oncogenic Mutant Stem Cells in Skin Epidermis In Vivo

2 citations , November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Mutant stem cells adapt their metabolism differently to outcompete normal cells in the skin.

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community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 479 upvotes 1 year ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 59 upvotes 2 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community Sucess story for you guys, pics are 10+ years apart.

in Progress Pictures 311 upvotes 1 year ago

A user shared a success story showing hair regrowth over 10 years, attributing it to quitting creatine and taking 0.5mg finasteride. Some commenters were skeptical about creatine's impact, while others inquired about side effects, and the original poster reported no negative effects from finasteride.