research Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors
Inactive hair follicle stem cells help prevent skin cancer.
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5 / 37 results research Tumor Suppressor Identity Contributes to Phenotype Heterogeneity in Hair Follicle Stem Cell-Induced Squamous Cell Carcinoma
The type of tumor suppressor affects the form of skin cancer from hair follicle stem cells.
research Oncogenic Ras Mutation Induces Spatiotemporally Specific Tissue Deformation Through Converting Fluctuated Into Sustained ERK Activation
A specific mutation in Kras causes abnormal tissue changes by making a cell signal continuously active, which disrupts normal cell coordination.
research Activated KRAS Alters Epidermal Homeostasis of Mouse Skin, Resulting in Redundant Skin and Defective Hair Cycling
Activating Kras in mouse skin causes excess skin and hair loss.
research KRASG12D Mutant Cells Are Outcompeted by Wild Type Neighbors in Adult Pancreas in an EPHA2-Dependent Manner
Normal cells outcompete and remove mutant cells in the pancreas with the help of the EphA2 receptor.
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