A Connection Between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis

    May 2008 in “ Journal of proteome research
    Vukić Šoškić, Martina Klemm, Tassula Proikas‐Cezanne, Gerhard P. Schwall, Slobodan Poznanović, Werner Stegmann, Karlfried Groebe, Helmut Zengerling, Rainer Schoepf, Michael Burnet, André Schrattenholz
    Image of study
    TLDR Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.
    In the study from 2008, researchers investigated the neuroprotective effects of 4-azasteroids, specifically focusing on dutasteride, which was found to inhibit the mitochondrial permeability transition pore and increase autophagosomal structures in human cell lines. The in vivo experiments showed a notable decrease in β-amyloid plaque load in a model for cerebral amyloidosis, suggesting a link between the release of neurotoxic peptides, mitochondrial apoptosis, and autophagy. This connection could have implications for understanding and potentially treating neurodegenerative diseases associated with amyloid plaque formation, such as Alzheimer's disease.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Fin 4+ years. March 2020 to March 2024

      in Progress Pictures  977 upvotes 1 year ago
      The user has been using finasteride for over four years with minimal side effects, successfully stopping hair thinning and achieving some regrowth. They shared progress photos, but some commenters requested clearer pictures of the crown to better assess the treatment's effectiveness.

      community Minoxidil&Finasteride 7 months progress

      in Progress Pictures  936 upvotes 1 year ago
      A user shared their 7-month progress using Minoxidil and Finasteride for hair loss, which significantly reversed their aging appearance. They applied Minoxidil twice daily, took 1mg Finasteride once daily, micro-needled weekly, maintained a high protein diet with vitamins and biotin, and recommended a balanced lifestyle for best results.

      community 4 months of low-dose Minoxidil

      in Progress Pictures  270 upvotes 1 week ago
      A 21-year-old male used low-dose 5% topical Minoxidil inconsistently for four months, resulting in stopped hair shedding and improved hair density, though the hairline remained unchanged. Users discussed the potential use of finasteride and other treatments, with some suggesting consulting a dermatologist for further advice.

    Similar Research

    5 / 1000+ results