A Connection Between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis

    May 2008 in “ Journal of proteome research
    Vukić Šoškić, Martina Klemm, Tassula Proikas‐Cezanne, Gerhard P. Schwall, Slobodan Poznanović, Werner Stegmann, Karlfried Groebe, Helmut Zengerling, Rainer Schoepf, Michael Burnet, André Schrattenholz
    Image of study
    TLDR Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.
    In the study from 2008, researchers investigated the neuroprotective effects of 4-azasteroids, specifically focusing on dutasteride, which was found to inhibit the mitochondrial permeability transition pore and increase autophagosomal structures in human cell lines. The in vivo experiments showed a notable decrease in β-amyloid plaque load in a model for cerebral amyloidosis, suggesting a link between the release of neurotoxic peptides, mitochondrial apoptosis, and autophagy. This connection could have implications for understanding and potentially treating neurodegenerative diseases associated with amyloid plaque formation, such as Alzheimer's disease.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Fin 4+ years. March 2020 to March 2024

      in Progress Pictures  976 upvotes 10 months ago
      The user has been using finasteride for over four years with minimal side effects, successfully stopping hair thinning and achieving some regrowth. They shared progress photos, but some commenters requested clearer pictures of the crown to better assess the treatment's effectiveness.
      [object Object]

      community Minoxidil&Finasteride 7 months progress

      in Progress Pictures  936 upvotes 1 year ago
      A user shared their 7-month progress using Minoxidil and Finasteride for hair loss, which significantly reversed their aging appearance. They applied Minoxidil twice daily, took 1mg Finasteride once daily, micro-needled weekly, maintained a high protein diet with vitamins and biotin, and recommended a balanced lifestyle for best results.

      community 4 Months (Fin + Duta + Minoxidil + Micro)

      in Progress Pictures  265 upvotes 4 days ago
      The conversation discusses a hair loss treatment regimen including finasteride, dutasteride, minoxidil, tretinoin, microneedling, and red light therapy. The user plans to update on progress after eight months.

      community 4 months!! We making progress!!

      in Progress Pictures  475 upvotes 1 week ago
      A user shared their successful hair regrowth journey using 0.5 mg Dutasteride, 2.5 mg oral Minoxidil, and Biotin gummies, after switching from Finasteride due to insomnia. They highlighted the importance of brushing the scalp for blood flow and reported significant progress in four months without side effects.

    Similar Research

    5 / 1000+ results