A Connection Between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis

    May 2008 in “ Journal of proteome research ”
    Vukić Šoškić, Martina Klemm, Tassula Proikas‐Cezanne, Gerhard P. Schwall, Slobodan Poznanović, Werner Stegmann, Karlfried Groebe, Helmut Zengerling, Rainer Schoepf, Michael Burnet, André Schrattenholz
    Image of study
    TLDR Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.
    In the study from 2008, researchers investigated the neuroprotective effects of 4-azasteroids, specifically focusing on dutasteride, which was found to inhibit the mitochondrial permeability transition pore and increase autophagosomal structures in human cell lines. The in vivo experiments showed a notable decrease in β-amyloid plaque load in a model for cerebral amyloidosis, suggesting a link between the release of neurotoxic peptides, mitochondrial apoptosis, and autophagy. This connection could have implications for understanding and potentially treating neurodegenerative diseases associated with amyloid plaque formation, such as Alzheimer's disease.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Fin 4+ years. March 2020 to March 2024

      in Progress Pictures  975 upvotes 1 year ago
      The user has been using finasteride for over four years with minimal side effects, successfully stopping hair thinning and achieving some regrowth. They shared progress photos, but some commenters requested clearer pictures of the crown to better assess the treatment's effectiveness.

      community Minoxidil&Finasteride 7 months progress

      in Progress Pictures  936 upvotes 1 year ago
      A user shared their 7-month progress using Minoxidil and Finasteride for hair loss, which significantly reversed their aging appearance. They applied Minoxidil twice daily, took 1mg Finasteride once daily, micro-needled weekly, maintained a high protein diet with vitamins and biotin, and recommended a balanced lifestyle for best results.

      community 4 months of min/fin treatment with little to no progress

      in Is this regrowth?  14 upvotes 3 days ago
      A 21-year-old male has been using finasteride and minoxidil for four months with little progress in hair regrowth, despite adding microneedling and rosemary oil to his routine. Users suggest patience, maintaining the current treatment, and possibly simplifying the routine by dropping rosemary and microneedling.

      community 4 and half month Finasteride, 2 months Minoxidil (oral)

      in Update  40 upvotes 6 days ago
      The user has been using 1.25 mg finasteride, 10 mg oral minoxidil, ketoconazole shampoo, and occasional micro-needling for hair loss, noting some regrowth, especially at the temples. Another user expresses relief and encouragement from the post, as they are starting similar treatments.

    Similar Research

    5 / 1000+ results