TLDR Exosomes from different stem cell sources affect immune cells and brain cell growth differently.
This study investigated the role of microRNA-enriched exosomes derived from mesenchymal stem cells (MSCs) from different tissue sources and their effects on immune cells and neurogenesis. Exosomes were purified from three sources, and RNA-Seq was used to identify and compare microRNAs between exosomes and their parental cells. The study found that the expression levels of several miRNAs varied among different MSCs and exosomes, and most miRNA profiles differed from their sources. Exosomes from different sources showed varying abilities to induce neurogenesis and angiogenesis and had diverse effects on PBMC proliferation, neutrophil survival, and NET formation. This research enhanced the understanding of the miRNA landscape in exosomes from hMSCs and their interactions with immune cells.
113 citations
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July 2020 in “International Journal of Molecular Sciences” 
25 citations
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May 2020 in “Stem Cells Translational Medicine” ADSC-CE treatment safely increases hair density and thickness in androgenetic alopecia patients.
263 citations
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February 2020 in “International journal of molecular sciences” ADSCs help in wound healing and skin regeneration but need more research for full understanding.
88 citations
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July 2019 in “International Journal of Molecular Sciences” Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.
136 citations
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May 2019 in “Cells” Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.
November 2023 in “Klìtinna ta organna transplantologìâ” MSC-derived exosomes can help treat COVID-19, hair loss, skin aging, and arthritis.
135 citations
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December 2015 in “Expert Opinion on Biological Therapy” Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.
January 2018 in “Stem cells in clinical applications” Exosomes show promise for tissue repair and regeneration with advantages over traditional cell therapies.
271 citations
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May 2019 in “Cells” The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.
December 2024 in “International Journal of Molecular Sciences” Human umbilical cord stem cell vesicles may help treat aging and related diseases.
