TLDR Exosomes from different stem cell sources affect immune cells and brain cell growth differently.
The study examined the effects of microRNA-enriched exosomes from mesenchymal stem cells (MSCs) derived from adipose tissue, bone marrow, and Wharton's jelly on immune cell functions and neurogenesis. It found that exosomes from different MSC sources had distinct microRNA profiles, which influenced their ability to modulate immune responses and promote neurogenesis. Bone marrow-derived exosomes were particularly effective in promoting neuronal differentiation and delaying neutrophil apoptosis, while adipose-derived exosomes enhanced neutrophil phagocytic capacity. Wharton's jelly-derived exosomes were most effective in promoting angiogenesis. These findings highlighted the potential therapeutic applications of MSC-derived exosomes in regenerative medicine and immune modulation. The study involved samples from 4 donors for each MSC source.
113 citations
,
July 2020 in “International Journal of Molecular Sciences” Allogenic ASCs and ECM transplants are safe and effective for tissue regeneration.
25 citations
,
May 2020 in “Stem Cells Translational Medicine” ADSC-CE treatment safely increases hair density and thickness in androgenetic alopecia patients.
263 citations
,
February 2020 in “International journal of molecular sciences” ADSCs help in wound healing and skin regeneration but need more research for full understanding.
88 citations
,
July 2019 in “International Journal of Molecular Sciences” Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.
136 citations
,
May 2019 in “Cells” Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.
November 2023 in “Klìtinna ta organna transplantologìâ” MSC-derived exosomes can help treat COVID-19, hair loss, skin aging, and arthritis.
135 citations
,
December 2015 in “Expert Opinion on Biological Therapy” Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.
January 2018 in “Stem cells in clinical applications” Exosomes show promise for tissue repair and regeneration with advantages over traditional cell therapies.
271 citations
,
May 2019 in “Cells” The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.
December 2024 in “International Journal of Molecular Sciences” Human umbilical cord stem cell vesicles may help treat aging and related diseases.
