MicroRNA-Enriched Exosomes from Different Sources of Mesenchymal Stem Cells Can Differentially Modulate Functions of Immune Cells and Neurogenesis

December 2021 in “ Biomedicines ”

Naina Soni, Suchi Gupta, Surender Rawat, V. Krishnakumar, Sujata Mohanty, Arup Banerjee

microRNA exosomes mesenchymal stem cells neurogenesis angiogenesis PBMC neutrophil NET formation

Studysummary This study found that exosomes from different mesenchymal stem cell sources had distinct effects on immune cell functions and varied microRNA expression profiles compared to their original cells.

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The study examined the effects of microRNA-enriched exosomes from mesenchymal stem cells (MSCs) derived from adipose tissue, bone marrow, and Wharton's jelly on immune cell functions and neurogenesis. It found that exosomes from different MSC sources had distinct microRNA profiles, which influenced their ability to modulate immune responses and promote neurogenesis. Bone marrow-derived exosomes were particularly effective in promoting neuronal differentiation and delaying neutrophil apoptosis, while adipose-derived exosomes enhanced neutrophil phagocytic capacity. Wharton's jelly-derived exosomes were most effective in promoting angiogenesis. These findings highlighted the potential therapeutic applications of MSC-derived exosomes in regenerative medicine and immune modulation. The study involved samples from 4 donors for each MSC source.

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