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GlossaryPeripheral Blood Mononuclear Cells (PBMC)

blood cells with a single round nucleus, like lymphocytes and monocytes

Peripheral Blood Mononuclear Cells (PBMCs) are a type of blood cell that has a single round nucleus, such as lymphocytes (T cells, B cells, NK cells) and monocytes. These cells are crucial for the immune system, as they play key roles in immune response and are often used in research and clinical studies to understand various diseases, including autoimmune disorders and infections.

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research The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring

1 citations , March 2023 in “Pharmaceutics”

PBMCsec can help reduce and improve thick skin scars.

research Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata

75 citations , October 2012 in “Journal of Investigative Dermatology”

Alopecia areata can be triggered by specific immune cells without genetic or environmental factors.

research Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege

53 citations , September 2013 in “Journal of Investigative Dermatology”

Hair follicle cells help protect against immune attacks by regulating T-cell activity.

research Abnormal Epigenetic Modifications in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata

48 citations , September 2011 in “British Journal of Dermatology”

Epigenetic changes in blood cells may contribute to alopecia areata.

research Novel TMEM173 Mutation and the Role of Disease-Modifying Alleles

47 citations , December 2019 in “Frontiers in immunology”

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

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