Randomized Clinical Trial of Astaxanthin Supplement on Serum Inflammatory Markers and ER Stress-Apoptosis Gene Expression in PBMCs of Women with PCOS
July 2024
in “
Journal of Cellular and Molecular Medicine
”
Studysummary In this study, women with PCOS who took 12 mg of Astaxanthin daily for 8 weeks showed a reduction in certain inflammatory markers and apoptosis-related genes, suggesting potential benefits for managing PCOS, though effects on symptoms like BMI and hirsutism were not significant.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This randomized, double-blind clinical trial examined the effects of astaxanthin (ASX) supplementation on inflammatory markers and gene expression related to ER stress-apoptosis in 56 women with polycystic ovary syndrome (PCOS). Over 8 weeks, ASX significantly reduced inflammatory cytokines IL-18, IL-6, and TNF-α, but had no significant impact on CRP levels, BMI, hirsutism, hair loss, or menstrual cycle regularity. The study suggests ASX may help reduce inflammation and cellular stress in PCOS, though improvements in clinical symptoms were not statistically significant, indicating the need for further research with larger sample sizes and longer durations.
