Effects of Supplementation with Two Probiotic Strains (Lactobacillus Helveticus and Bifidobacterium Longum) on Hormonal Status, Oxidative Stress, and Clinical Symptoms in Women with Polycystic Ovary Syndrome: A Randomized Clinical Trial

    November 2025 in “ Nutrition Journal
    Mahsa Shirani, Mohammad Bagherniya, Omid Sadeghi … Gholamreza Askari
    Studysummary This study found that an 8-week supplementation with specific probiotic strains improved hormonal markers and oxidative stress while decreasing inflammation in women with PCOS, although clinical symptoms like acne and hirsutism showed no significant improvement compared to the placebo group.
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    Research cited in this study 6

    1. Physiopathology of Polycystic Ovary Syndrome in Endocrinology, Metabolism, and Inflammation Journal of Ovarian Research · 2025
    2. Polycystic Ovary Syndrome and Oxidative Stress: From Bench to Bedside International journal of molecular sciences · 2023
    3. The Role of Probiotics and Synbiotics on Hirsutism Fermentation · 2021
    4. Understanding Variation in Prevalence Estimates of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Human Reproduction Update · 2018
    5. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    6. Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss F1000Research · 2015