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GlossaryOtotoxicity

property of being toxic to the ear, causing hearing loss

Ototoxicity refers to the property of being toxic to the ear, specifically the cochlea or auditory nerve and sometimes the vestibular system, which can result in hearing loss or balance disorders. This condition is often caused by certain medications or chemicals, such as aminoglycoside antibiotics or chemotherapy agents, which can damage the inner ear structures.

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Effect of Low-Level Laser Therapy on Hair Cell Regeneration Following Gentamicin-Induced Ototoxicity in Postnatal Organotypic Culture of Rat Cochlea

research Effect of Low-Level Laser Therapy on Hair Cell Regeneration Following Gentamicin-Induced Ototoxicity in Postnatal Organotypic Culture of Rat Cochlea

1 citations , February 2010 in “Proceedings of SPIE”

Low level laser therapy may help regenerate hair cells in the ear after damage from gentamicin.

Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

research Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

8 citations , June 2021 in “International Journal of Molecular Sciences”

Exosomes from umbilical cord cells fix hearing loss and damaged ear hair cells in mice.

Estradiol Protects Hair Cells From Cisplatin-Induced Ototoxicity Via Nrf2 Activation

research Estradiol Protects Hair Cells From Cisplatin-Induced Ototoxicity Via Nrf2 Activation

2 citations , January 2023 in “Redox Report”

Estradiol may protect ear cells from hearing loss caused by a chemotherapy drug by activating a protective pathway.

research Sesn2/AMPK/mTOR Signaling Mediates Balance Between Survival and Apoptosis in Sensory Hair Cells Under Stress

21 citations , October 2017 in “Cell death and disease”

Sesn2 protects inner ear hair cells from damage by regulating certain cell survival pathways.

research Metformin Protects Against Gentamicin-Induced Hair Cell Death In Vitro But Not Ototoxicity In Vivo

26 citations , September 2014 in “Neuroscience Letters”

Metformin protects hair cells in lab tests but not in live animals.

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