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GlossaryOtotoxicity

property of being toxic to the ear, causing hearing loss

Ototoxicity refers to the property of being toxic to the ear, specifically the cochlea or auditory nerve and sometimes the vestibular system, which can result in hearing loss or balance disorders. This condition is often caused by certain medications or chemicals, such as aminoglycoside antibiotics or chemotherapy agents, which can damage the inner ear structures.

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research Ototoxicity of Common Topical Antimycotic Preparations

65 citations, April 2000 in “The Laryngoscope”

Clotrimazole, miconazole, and tolnaftate are likely safe, but gentian violet is risky.

research Estradiol Protects Hair Cells From Cisplatin-Induced Ototoxicity Via Nrf2 Activation

2 citations, January 2023 in “Redox Report”

Estradiol may protect ear cells from hearing loss caused by a chemotherapy drug by activating a protective pathway.

Effect of Low-Level Laser Therapy on Hair Cell Regeneration Following Gentamicin-Induced Ototoxicity in Postnatal Organotypic Culture of Rat Cochlea

research Effect of Low-Level Laser Therapy on Hair Cell Regeneration Following Gentamicin-Induced Ototoxicity in Postnatal Organotypic Culture of Rat Cochlea

1 citations, February 2010 in “Proceedings of SPIE”

Low level laser therapy may help regenerate hair cells in the ear after damage from gentamicin.

research Deferoxamine Protects Cochlear Hair Cells Against Tert-Butyl Hydroperoxide-Induced Ototoxicity

March 2024 in “Biochimica et biophysica acta. Molecular basis of disease”

Deferoxamine may help protect inner ear cells from damage caused by oxidative stress.

research Sesn2/AMPK/mTOR Signaling Mediates Balance Between Survival and Apoptosis in Sensory Hair Cells Under Stress

21 citations, October 2017 in “Cell death and disease”

Sesn2 protects inner ear hair cells from damage by regulating certain cell survival pathways.

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