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GlossaryOtotoxicity

property of being toxic to the ear, causing hearing loss

Ototoxicity refers to the property of being toxic to the ear, specifically the cochlea or auditory nerve and sometimes the vestibular system, which can result in hearing loss or balance disorders. This condition is often caused by certain medications or chemicals, such as aminoglycoside antibiotics or chemotherapy agents, which can damage the inner ear structures.

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research Ototoxicity of Common Topical Antimycotic Preparations

65 citations , April 2000 in “The Laryngoscope”

Clotrimazole, miconazole, and tolnaftate are likely safe, but gentian violet is risky.

research Metformin Protects Against Gentamicin-Induced Hair Cell Death In Vitro But Not Ototoxicity In Vivo

26 citations , September 2014 in “Neuroscience Letters”

Metformin protects hair cells in lab tests but not in live animals.

Estradiol Protects Hair Cells From Cisplatin-Induced Ototoxicity Via Nrf2 Activation

research Estradiol Protects Hair Cells From Cisplatin-Induced Ototoxicity Via Nrf2 Activation

2 citations , January 2023 in “Redox Report”

Estradiol may protect ear cells from hearing loss caused by a chemotherapy drug by activating a protective pathway.

Effect of Low-Level Laser Therapy on Hair Cell Regeneration Following Gentamicin-Induced Ototoxicity in Postnatal Organotypic Culture of Rat Cochlea

research Effect of Low-Level Laser Therapy on Hair Cell Regeneration Following Gentamicin-Induced Ototoxicity in Postnatal Organotypic Culture of Rat Cochlea

1 citations , February 2010 in “Proceedings of SPIE”

Low level laser therapy may help regenerate hair cells in the ear after damage from gentamicin.

Deferoxamine Protects Cochlear Hair Cells Against Tert-Butyl Hydroperoxide-Induced Ototoxicity

research Deferoxamine Protects Cochlear Hair Cells Against Tert-Butyl Hydroperoxide-Induced Ototoxicity

March 2024 in “Biochimica et biophysica acta. Molecular basis of disease”

Deferoxamine may help protect inner ear cells from damage caused by oxidative stress.

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