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    Glossary Ototoxicity

    property of being toxic to the ear, causing hearing loss

    Ototoxicity refers to the property of being toxic to the ear, specifically the cochlea or auditory nerve and sometimes the vestibular system, which can result in hearing loss or balance disorders. This condition is often caused by certain medications or chemicals, such as aminoglycoside antibiotics or chemotherapy agents, which can damage the inner ear structures.

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    Research 30 of 97

    1. Ototoxicity of Common Topical Antimycotic Preparations The Laryngoscope · 2000 · 65 citations
    2. Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo Neuroscience Letters · 2014 · 26 citations
    3. Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation Redox Report · 2023 · 2 citations
    4. Effect of low level laser therapy on hair cell regeneration following gentamicin induced ototoxicity in postnatal organotypic culture of rat cochlea Proceedings of SPIE · 2010 · 1 citations
    5. Deferoxamine protects cochlear hair cells and hair cell-like HEI-OC1 cells against tert-butyl hydroperoxide-induced ototoxicity Biochimica et biophysica acta. Molecular basis of disease · 2024
    6. Inositol hexaphosphate alleviates ototoxicity and age‐related hearing loss by preserving cochlear hair cells in mice British Journal of Pharmacology · 2025
    7. Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress Cell death and disease · 2017 · 21 citations
    8. Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice International Journal of Molecular Sciences · 2021 · 8 citations
    9. Hair cell toxicology: With the help of a little fish Frontiers in cell and developmental biology · 2022 · 4 citations
    10. Toxic Effect of Platinum Compounds: Molecular Mechanisms of Toxicity ˜Al-œRafidain journal of medical sciences. · 2021 · 1 citations
    11. Autophagy-related protein 12 associates with anti-apoptotic B cell lymphoma-2 to promote apoptosis in gentamicin-induced inner ear hair cell loss Molecular Medicine Reports · 2017 · 2 citations
    12. Mesenchymal stem cell-derived exosomes ameliorate gentamicin-induced vestibular hair cell injury by regulating the SNARE pathway and enhancing autophagy Stem Cell Research & Therapy · 2025 · 1 citations
    13. The side effects of platinum-based chemotherapy drugs: a review for chemists Dalton transactions · 2018 · 1108 citations
    14. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 65 citations
    15. Environmental exposure to platinum group elements released by automotive catalytic converters: the risk for children International journal of environment and health · 2008 · 11 citations
    16. Diuretics Elsevier eBooks · 2017 · 1 citations
    17. Vestibular Hair Cell Regeneration and Restoration of Balance Function Induced by Math1 Gene Transfer Otology & Neurotology · 2007 · 129 citations
    18. Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy Gynecologic oncology · 2004 · 127 citations
    19. Live imaging of skin immunity using two-photon microscopy: a short review Inflammation and Regeneration · 2026
    20. Use of chemotherapy during human pregnancy Lancet Oncology · 2004 · 724 citations
    21. The transdermal inhibition of melanogenesis by a cell-membrane-permeable peptide delivery system based on poly-arginine Biomaterials · 2014 · 36 citations
    22. Pegylated-interferon-α<sub>2a</sub>in clinical practice: how to manage patients suffering from side effects Expert Opinion on Drug Safety · 2011 · 17 citations
    23. A bibliometric study of scientific literature in Scopus on botanicals for treatment of androgenetic alopecia Journal of Cosmetic Dermatology · 2015 · 15 citations
    24. Wound healing mechanism in Mongolian gerbil skin Histochemistry and Cell Biology · 2018 · 6 citations
    25. Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress Basic & Clinical Pharmacology & Toxicology · 2021 · 5 citations
    26. Side Effects and Adverse Events After Treatment With Teprotumumab for Thyroid Eye Disease: A Retrospective Observational Case Series Curēus · 2024
    27. Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling Biocell · 2023
    28. Reporting on Adverse Clinical Events Clin-Alert · 2021
    29. A prospective observational study on drug safety monitoring and Pharmacoeconomics in patients with locally advanced unresectable NSCLC in a tertiary care hospital International journal of basic and clinical pharmacology · 2018
    30. Cochlea hair cell rescue after a noise-induced hearing loss using a low level laser therapy (LLLT) 2011