Melatonin Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2/ROS/NLRP3 Pathway

November 2022 in “ Molecular Neurobiology ”

Yu Zheng, Na Gao, Weixun Zhang, Rui Ma, Fang‐Lu Chi, Zhen Gao, Cong Ning

melatonin oxygen-glucose deprivation/reperfusion OGD/R HEI-OC1 cells cochlear hair cells pyroptosis ROS luzindole Nrf2 ML385 MT-1 MT-2 NLRP3 idiopathic sudden sensorineural hearing loss reactive oxygen species

TLDR Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

The study examined the impact of melatonin on oxygen-glucose deprivation/reperfusion (OGD/R) in HEI-OC1 cells and cochlear hair cells, which simulate cochlear ischemia-reperfusion injury. Results indicated that melatonin protected these cells from OGD/R-induced cell pyroptosis and decreased ROS expression levels. However, these effects were nullified by luzindole, a non-selective melatonin receptor blocker, and largely counteracted by ML385, an Nrf2 inhibitor. The study concludes that melatonin mitigates OGD/R-induced pyroptosis in hair cells through the MT-1, MT-2/Nrf2/ROS/NLRP3 pathway, suggesting melatonin could be a potential treatment for idiopathic sudden sensorineural hearing loss.

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