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Melatonin Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2/ROS/NLRP3 Pathway

research Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway

5 citations , November 2022 in “Molecular Neurobiology”

Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

research Melatonin Receptor MT1 is Expressed in Mouse Skin and In vitro Melatonin Treatment Enhances Whisker Growth

1 citations , January 2013 in “Journal of clinical & experimental dermatology research”

This study found that melatonin enhanced whisker growth in vitro and identified MT1 receptor presence in the granular layer of mouse epidermis and the outer root sheath, suggesting potential for hair growth treatment.

research Re: The association of urolithiasis and androgenetic alopecia. Resorlu M, Sancak EB, Uysal F, Arslan M, Diri A, Adam G, Akbas A, Sariyildirim A, Gulpinar MT, Resorlu B. Ren Fail. 2015 Oct 13:1–5

January 2016 in “Renal Failure”

Kidney stones and hair loss are significantly related in people under 60 years old.

Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

research Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFκB and AP-1

1 citations , February 2023 in “International Journal of Molecular Sciences”

This study found that exogenous melatonin improved cashmere fiber quality and yield in goats by enhancing antioxidant capacity and reducing pro-aging cytokine expression in secondary hair follicles.

Maternal Melatonin Contributes to Offspring Hair Follicle Development Through Transcriptional Regulation of the AP-1 Complex and MAPK Pathway

research Maternal Melatonin Contributes to Offspring Hair Follicle Development Through Transcriptional Regulation of the AP-1 Complex and MAPK Pathway

February 2025 in “International Journal of Molecular Sciences”

In this study, maternal melatonin implantation in pregnant rabbits reduced hair follicle cell apoptosis and increased hair follicle density in their neonatal offspring, suggesting a beneficial impact on hair follicle development mediated through specific molecular pathways.

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community 25M - 1.6 years on treatment (diffuse thinning)

in Progress Pictures 268 upvotes 7 months ago

A 25-year-old male has been using 0.5mg dutasteride and 5mg minoxidil for 1.6 years to treat diffuse thinning, with significant hair regrowth except for the hairline. He plans to get a hair transplant for further improvement and reports no side effects from the treatment.

community 18M 8 months progress 40mg daily dut stack

in Progress Pictures 112 upvotes 1 year ago

An 18-year-old is using a high-dose hair loss treatment with 40mg daily dutasteride, finasteride, minoxidil, tretinoin, and topical bicalutamide. Despite health risk concerns, especially liver issues, they report hair regrowth progress and intend to continue the regimen.

community 2 years fin only 1mg/daily + 4 months of gradually introducing Dut 0.5mg/daily

1706 upvotes 11 months ago

A user experienced significant hair regrowth using finasteride 1 mg daily for two years and gradually introduced dutasteride 0.5 mg daily over four months. They reported no side effects and plan to switch fully to dutasteride due to its cost-effectiveness and potential effectiveness.

community Am I crazy for thinking finasteride's done nothing for me? 18 y/o vs. 21 (10 months finasteride + minoxidil)

in Progress Pictures 51 upvotes 3 months ago

Finasteride and minoxidil have helped maintain hair density and possibly improved coverage, though results vary and regrowth can take time. Some suggest trying dutasteride and oral minoxidil for more significant regrowth.

community [32M] 4 months into 5mg fin and oral min. (Oct. ‘25 vs. Jan ‘26)

895 upvotes 7 months ago

A 32-year-old man experienced positive hair regrowth after 4 months using 1.2mg finasteride and 3mg oral minoxidil, with no side effects. He used a chewable combo pill from Hims, noting minoxidil aids regrowth and finasteride maintains hair.

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