cells undergoing programmed cell death with fragmented DNA
TUNEL-positive cells are cells that have been identified as undergoing apoptosis, or programmed cell death. The TUNEL (Terminal deoxynucleotidyl transferase dUTP Nick End Labeling) assay is a laboratory technique used to detect DNA fragmentation, a hallmark of apoptosis, by labeling the ends of broken DNA strands. This helps researchers and medical professionals understand cell death processes in various conditions, including diseases and tissue development.
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