Sulfotransferases, Sulfatases, and Formylglycine-Generating Enzymes: A Sulfation Fascination
July 2008
in “
Current Opinion in Chemical Biology
”
TLDR The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.
The 2008 document reviewed advances in the understanding of sulfotransferases, sulfatases, and formylglycine-generating enzymes (FGEs), highlighting their structural characteristics, mechanisms, and roles in human biology and disease. It discussed the identification of three new human sulfatase genes, the mechanism of FGEs in converting cysteine to formylglycine, and the implications of their dysfunction in multiple sulfatase deficiency (MSD). The review also covered the discovery of a new sulfated metabolite in Mycobacterium tuberculosis, the structure of a bacterial sulfotransferase involved in sulfated antibiotic biosynthesis, and the inactivation of sulfatases by aryl sulfamates, which has clinical relevance. Additionally, it touched on the inhibition of steroid sulfatase as a potential breast cancer treatment. The document emphasized the importance of understanding sulfation biology for developing therapeutic inhibitors, given the significance of sulfation processes in various biological functions.
