Glutathione-S-Epoxide Transferase in Human Hair Follicles

April 1986 in “ Cancer Letters ”

A. C. Dijkstra, L.W. Misdom, C. M. A. A. Goos, M.W.A.C. Hukkelhoven, A.J.M. Vermorken

glutathione-S-epoxide transferase GSH-T hair follicles keratinocytes benz[a]anthracene clotrimazole skin fibroblasts polycyclic aromatic hydrocarbons PAHs

TLDR GSH-T levels in hair follicles are similar in smokers and non-smokers and don't increase with certain treatments.

A fluorometric assay was used to measure glutathione-S-epoxide transferase (GSH-T) activity in human hair follicles and cultured cells. The study found no significant difference in GSH-T levels between smokers and non-smokers. Additionally, GSH-T levels did not increase after treating cultured hair follicle keratinocytes with benz[a]anthracene or clotrimazole, nor in cultured skin fibroblasts from both Ah-responsive and Ah-non-responsive mice. The study discussed the potential importance of basal GSH-T levels in assessing the risk of carcinogenic effects from polycyclic aromatic hydrocarbons.

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research Rapid High-Performance Liquid Chromatographic Method for Detection of Interindividual Differences in Carcinogen Metabolism

9 citations, January 1983 in “Journal of Chromatography B Biomedical Sciences and Applications”

Human hair follicles can assess carcinogen metabolism and imidazole compounds might be effective anticarcinogens.

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