Rapid High-Performance Liquid Chromatographic Method for Detection of Interindividual Differences in Carcinogen Metabolism

January 1983 in “ Journal of Chromatography B Biomedical Sciences and Applications ”

M.W.A.C. Hukkelhoven, A. C. Dijkstra, A.J.M. Vermorken

hair follicles carcinogen metabolism benzo[a]pyrene coal tar enzyme activity imidazole compounds clotrimazole ketoconazole BP coal tar shampoo

TLDR Human hair follicles can assess carcinogen metabolism and imidazole compounds might be effective anticarcinogens.

This study demonstrated that human hair follicles could be used to assess carcinogen metabolism, specifically focusing on benzo[a]pyrene (BP) and its metabolites. Twelve volunteers used a coal tar-containing shampoo for 4 days, resulting in increased enzyme activity related to carcinogen metabolism in most subjects. The study found significant interindividual variation in basal enzyme activity and showed that enzyme activity could be inhibited by imidazole compounds like clotrimazole and ketoconazole. These findings suggested that hair follicles are a viable tissue for studying carcinogen metabolism and that imidazole compounds might be effective anticarcinogens.

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