TLDR Coal tar shampoo increases enzyme activity in hair follicles, enhancing carcinogen binding to DNA.
This study investigated the metabolism of carcinogens benzo[a]pyrene (BP) and benzo[a]pyrene-7,8-diol (BP 7,8-diol) in human hair follicles and the effect of a coal tar-containing (CCT) shampoo on these processes. Twelve healthy volunteers used the shampoo daily for 4 days, resulting in increased enzyme activity (50-148%) in 10 of them, which enhanced the binding of BP to DNA. The study also found that clotrimazole and ketoconazole significantly inhibited this enzyme activity. These findings suggested that hair follicles are a viable tissue for studying PAH metabolism and that imidazole compounds could potentially act as anticarcinogens.
9 citations,
January 1983 in “Journal of Chromatography B Biomedical Sciences and Applications” Human hair follicles can assess carcinogen metabolism and imidazole compounds might be effective anticarcinogens.
38 citations,
June 2018 in “Archives of Toxicology” Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
January 2013 in “Springer eBooks” Hair care products are important for appearance and self-esteem, and choosing the right ones can help maintain healthy hair.
67 citations,
April 2007 in “Journal der Deutschen Dermatologischen Gesellschaft” Shampoos are designed to clean and improve hair and scalp health, with specific ingredients for different hair types and conditions.
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August 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Modulating Cytochrome P450 activity could help develop new skin disease treatments.
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January 2021 in “Skin appendage disorders” Smoking is linked to more hair loss and premature graying compared to nonsmokers.
