Human Hair Follicle Benzo[a]pyrene and Benzo[a]pyrene 7,8-diol Metabolism: Effect of Exposure to a Coal Tar-Containing Shampoo

    January 1987 in “ Journal of Investigative Dermatology ”
    Marcus Maurer, Hasan Mukhtar, Irene Kaufmann, Mukul Das, David R. Bickers
    TLDR Coal tar shampoo increases enzyme activity in hair follicles, enhancing carcinogen binding to DNA.
    This study investigated the metabolism of carcinogens benzo[a]pyrene (BP) and benzo[a]pyrene-7,8-diol (BP 7,8-diol) in human hair follicles and the effect of a coal tar-containing (CCT) shampoo on these processes. Twelve healthy volunteers used the shampoo daily for 4 days, resulting in increased enzyme activity (50-148%) in 10 of them, which enhanced the binding of BP to DNA. The study also found that clotrimazole and ketoconazole significantly inhibited this enzyme activity. These findings suggested that hair follicles are a viable tissue for studying PAH metabolism and that imidazole compounds could potentially act as anticarcinogens.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 29 results

      community Recovered from dark finasteride side effects

      in Finasteride/Dutasteride  6 upvotes 4 years ago
      The user experienced severe side effects from finasteride, including depression and anxiety, but recovered with DHT injections, sleep medication, and Ayurvedic treatments. They now maintain hair health with minoxidil, PRP therapy, and a good diet, advising against self-diagnosis and recommending consulting a doctor.

      community Jordan Peterson got a sick hair transplant!

      in Transplants  1074 upvotes 2 years ago
      The conversation is about Jordan Peterson allegedly getting a hair transplant, with various users mocking his way of speaking and debating the ethics of him potentially hiding the procedure. Some users discuss the natural look of the transplant and the implications of getting one at an older age.

      community Do it yourself topical Fin and Min solution works

      in Progress Pictures  119 upvotes 5 months ago
      A homemade topical solution of finasteride and minoxidil effectively stopped hair shedding and promoted regrowth without side effects. Users shared experiences and discussed different concentrations and application methods.

      community 23M Couldn’t go bald for fear of my Girlfriend leaving me.

      in Is this regrowth?  1092 upvotes 6 months ago
      A 23-year-old man uses a topical spray with minoxidil, finasteride, and tretinoin for hair loss, experiencing improved hair growth but occasional heart palpitations. He worries his girlfriend might leave him if he goes bald, but commenters advise that if she would leave over hair loss, she isn't worth it.

    Similar Research

    5 / 396 results