Human Hair Follicle Benzo[a]pyrene and Benzo[a]pyrene 7,8-diol Metabolism: Effect of Exposure to a Coal Tar-Containing Shampoo

    January 1987 in “ Journal of Investigative Dermatology ”
    Marcus Maurer, Hasan Mukhtar, Irene Kaufmann, Mukul Das, David R. Bickers
    TLDR Coal tar shampoo increases enzyme activity in hair follicles, enhancing carcinogen binding to DNA.
    This study investigated the metabolism of carcinogens benzo[a]pyrene (BP) and benzo[a]pyrene-7,8-diol (BP 7,8-diol) in human hair follicles and the effect of a coal tar-containing (CCT) shampoo on these processes. Twelve healthy volunteers used the shampoo daily for 4 days, resulting in increased enzyme activity (50-148%) in 10 of them, which enhanced the binding of BP to DNA. The study also found that clotrimazole and ketoconazole significantly inhibited this enzyme activity. These findings suggested that hair follicles are a viable tissue for studying PAH metabolism and that imidazole compounds could potentially act as anticarcinogens.
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