Cytochrome P450: A Target for Drug Development for Skin Diseases

    August 2004 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Nihal Ahmad, Hasan Mukhtar
    TLDR Modulating Cytochrome P450 activity could help develop new skin disease treatments.
    The document discussed the role of cytochrome P450 (CYP) enzymes in skin diseases and their potential as targets for drug development. It highlighted the importance of understanding CYP mechanisms to develop better therapeutic strategies for skin disorders, noting that most dermatological drugs interact with CYP enzymes. The review emphasized the significant increase in CYP1B1 mRNA in human keratinocytes treated with certain chemicals and the role of CYP enzymes in metabolizing skin carcinogens. Studies showed that CYP inhibitors could enhance the therapeutic effects of retinoic acid and vitamin D, offering new treatments for conditions like psoriasis. Additionally, the document noted the effectiveness of CYP-based drugs like liarozole and ketoconazole in treating various skin conditions and emphasized the need for further research on CYP enzymes to develop novel therapeutic strategies.
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