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      research Cytochrome P450: A Target for Drug Development for Skin Diseases

      115 citations , August 2004 in “˜The œjournal of investigative dermatology/Journal of investigative dermatology”
      This review discusses the role of cytochrome P450 enzymes in skin metabolism and drug development for skin diseases, highlighting their importance and suggesting further research, but reports no new experimental findings.

      research Interaction of antiretroviral medications with finasteride

      November 2012 in “Journal of the International AIDS Society”
      This observational study suggests that antiretroviral drugs that interact with CYP 3A4 enzymes may alter finasteride's effectiveness for hair loss in men treated for HIV.

      research S100A8 induces cyclophosphamide-induced alopecia via NCF2/NOX2-mediated ferroptosis

      2 citations , February 2025 in “Free Radical Biology and Medicine”
      In a mouse model of chemotherapy-induced alopecia, this study found that inhibiting the protein S100A8 with paquinimod alleviated hair loss and reduced oxidative stress and ferroptosis, suggesting a potential therapeutic strategy for managing this side effect in chemotherapy patients.
      Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

      research Antiandrogens and Androgen Inhibitors

      November 2020 in “Elsevier eBooks”
      This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.

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    5 / 15 results

      community Will taking hair loss orals affect trt?

       5 upvotes 1 week ago
      Taking finasteride or dutasteride with testosterone replacement therapy (TRT) can increase testosterone levels by blocking its conversion to DHT, potentially raising estrogen levels. Users suggest monitoring for high estrogen symptoms and possibly using an aromatase inhibitor like anastrozole if needed.

      community How much more risk does TRT really put on hair?

       2 upvotes 1 month ago
      TRT may increase hair loss, but using treatments like dutasteride, minoxidil, and RU58841 can help mitigate it. Individual responses vary, and some users report regrowth while others see stabilization or continued loss.

      community Oral Minoxidil and Grapefruit Juice

      in Research/Science  96 upvotes 3 years ago
      The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

      community 2.5 years 1mg finasteride daily

       4887 upvotes 8 months ago
      Significant hair regrowth was achieved after 2.5 years of taking 1 mg finasteride daily, without using minoxidil or microneedling. Minor side effects included a slightly thinner beard and longer time to finish during sex.

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      learn Cyproterone

      a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor