Glutathione S-Transferase Gene Polymorphism, Total Antioxidant Status, And Blood Pressure Changes In Androgenic Alopecia

    May 2025 in “ Anadolu Kliniği Tıp Bilimleri Dergisi ”
    Abdüsselam Şekerci, Gökhan Bağcı, Hande Küçük Kurtulgan, Ferhan Candan
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    Studysummary This study found that in male patients with androgenic alopecia, individuals with certain glutathione S-transferase gene polymorphisms exhibited higher oxidative stress and lower antioxidant capacity, although differences were not statistically significant, and oxidative stress appeared to increase with the progression of alopecia stages. Our plain-language summary of this paper — not a Tressless recommendation.
    The study on 43 male patients with androgenic alopecia (AGA) explored the link between glutathione S-transferase (GST) gene polymorphisms, total antioxidant status (TAS), and blood pressure changes. It found that GST gene polymorphisms might be related to increased oxidative stress and decreased TAS in AGA patients. Specifically, the GSTP1 A114V heterozygous genotype was associated with higher total oxidative stress (TOS) levels, and the GSTT1 null genotype was linked to lower TAS. Although not statistically significant, a positive correlation was noted between AGA stages and oxidative stress, suggesting oxidative stress may rise as AGA progresses.
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