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research Comparison of Activities Dependent on Glutathione S-Transferase and Cytochrome P-450 IA1 in Cultured Keratinocytes and Reconstructed Epidermal Models

42 citations , January 2002 in “Skin Pharmacology and Physiology”

This study reported that reconstructed skin models can be useful for studying the effects of non-water-soluble topical products on xenobiotic metabolism, particularly in enzyme activities like EROD and GST.

research Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403.

1 citations , September 2001 in “PubMed”

This study found that the serine protease inhibitor ONO-3403 significantly suppressed tumor growth in mice with induced squamous cell carcinoma without apparent side effects, suggesting its potential for cancer treatment.

research 138 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, the reconstructed skin epidermal model derived from hair follicles showed gene expression and enzyme functionality consistent with native human skin, suggesting its viability for studying skin metabolism and potential toxicity of dermo-cosmetic ingredients.

research The lipide composition of epidermis and dermis of mice undergoing carcinogenesis by methylcholanthrene.

5 citations , January 1961 in “PubMed”

This study found that the lipid composition of the epidermis varies significantly throughout the hair growth cycle and after applying methylcholanthrene, with notable differences observed between hyperplastic and carcinomatous conditions.

research Chemically Induced Depigmentation of Skin and Hair

January 1990 in “Springer eBooks”

Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.

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Community Join

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community 3 months into dut 25 days into oral minoxidil- crazy shedding in the last month

5 upvotes 8 hours ago

The conversation is about experiencing significant hair shedding after 3 months of using dutasteride and 25 days of oral minoxidil. Users suggest patience, wearing a hat, or buzzing the hair off.

community 3 Month Diffuse Thinner - Oral Min/Fin, RU, Derma Stamp, Nizoral Shampoo 2x Weekly

9 upvotes 2 days ago

The user reports progress in treating hair loss using oral minoxidil, finasteride, topical RU58841, a derma stamp, and ketoconazole shampoo. They experience no side effects from RU58841 and believe it acts locally.

community 3 semana con minoxidil saludos

3 days ago

Minoxidil has been used for three weeks, but improvements typically take at least three months. A DHT blocker is also recommended.

community 3 years on meds in total Nw3 now, so very confused

6 days ago

The user has been using finasteride, dutasteride, and plans to start oral minoxidil due to hair loss concerns, experiencing retrograde symptoms and reduced hair density. Despite others' opinions that their hair looks good, the user feels they have progressed to Norwood 3 and is unsure about the effectiveness of their treatment plan.

community 3 months vs 5 months Dutasteride progress

9 upvotes 6 days ago

The user switched from finasteride to oral dutasteride and is assessing hair regrowth progress after 5 months, with some users noting visible improvement in density and regrowth. The user is advised to continue with dutasteride as it may take over two years for full effects.

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Learn

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learn 3 aminopropane Sulfernic acid

learn Omega 3

Did you know omega-3 can lower scalp inflammation that leads to sudden hair loss? Omega-3 can reduce scalp inflammation, potentially preventing sudden hair loss.
Is the omega-3 to omega-6 ratio in your diet feeding your hair problem without you knowing? Nutrition sources describe a lopsided omega-6 to omega-3 intake as pro-inflammatory, but no published human study shows that the dietary ratio changes 5-alpha reductase, scalp DHT or hair loss; the one relevant trial tested a commercial omega-3/6 plus antioxidant supplement in 120 women, not a change in dietary fat ratio.
How can omega-3 supplements help reduce hair loss and support healthy hair growth? Omega-3 supplements may reduce hair loss by improving scalp health and circulation.
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learn acetyl tetrapeptide-3

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