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GlossaryCytochrome P450

enzymes metabolize drugs and toxins in the liver

Cytochrome P450 (CYP) refers to a large family of enzymes that play a crucial role in the metabolism of various substances within the body, including drugs, toxins, and hormones. These enzymes are primarily found in the liver and are essential for the detoxification process, as well as the synthesis of cholesterol, steroids, and other lipids.

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research Characterization of Xenobiotic Metabolizing Enzymes of a Reconstructed Human Epidermal Model from Adult Hair Follicles

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Identification of a Cyclosporine-Specific P450 Hydroxylase Gene Through Targeted Cytochrome P450 Complement Disruption in Sebekia Benihana

research Identification of a Cyclosporine-Specific P450 Hydroxylase Gene Through Targeted Cytochrome P450 Complement Disruption in Sebekia Benihana

13 citations, January 2013 in “Applied and Environmental Microbiology”

A gene in Sebekia benihana, CYP-sb21, is needed for a specific reaction on the drug Cyclosporine A, which could be important for hair growth without affecting the immune system.

research Cytochrome P450: A Target for Drug Development for Skin Diseases

115 citations, August 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

research Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models

38 citations, June 2018 in “Archives of Toxicology”

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

research A Novel Regio-Specific Cyclosporin Hydroxylase Gene Revealed Through the Genome Mining of Pseudonocardia Autotrophica

3 citations, March 2014 in “Journal of Industrial Microbiology & Biotechnology”

Scientists found a new gene in a bacterium that can modify an immunosuppressant drug, potentially helping to treat hair loss.

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community How does finasteride leave your body?

in Chat 13 upvotes 7 months ago

Finasteride is metabolized in the liver and excreted through urine and feces. Users humorously discuss its excretion, with one joking about it being expelled through ejaculation.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Should I apply my grapefruit topically instead of injecting it into my bloodstream?

in Satire 74 upvotes 1 year ago

The conversation is a satirical discussion about using grapefruit for hair regrowth, with suggestions ranging from injecting it to applying it topically or anally. Some users claim unusual benefits like emitting a green aura or jumping high.

community Fin/Dut and Metabolism Speeds…

in Finasteride/Dutasteride 8 upvotes 2 months ago

A user speculates that a fast metabolism might affect the effectiveness of dutasteride for hair loss. Another user argues that drug response is unrelated to metabolism speed.

community RU-58841 Lung Disease Possibility | Chest pain, "heart issues", etc

in Treatment 24 upvotes 8 months ago

Some users of RU-58841 report cardiovascular symptoms like heart palpitations and chest tightness, which may be linked to its metabolites causing lung disease. The safety of RU-58841 is uncertain due to lack of long-term data and concerns about product purity, especially from gray market sources.

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