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Glossary Voriconazole

antifungal drug treating serious fungal infections

Voriconazole is an antifungal medication used to treat serious fungal infections, such as aspergillosis and candidiasis. It works by inhibiting the growth of fungi, making it effective for patients with weakened immune systems. For professionals, it's important to note that Voriconazole is a triazole antifungal that inhibits the fungal cytochrome P450 enzyme 14α-demethylase, crucial for ergosterol synthesis in fungal cell membranes.

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Research

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research Adverse effects of voriconazole: Over a decade of use

100 citations , September 2016 in “Clinical transplantation/Clinical transplantation.”

This study highlights that prolonged voriconazole use is linked to an increased risk of aggressive cutaneous malignancies like squamous cell carcinoma, necessitating careful monitoring of drug levels to manage adverse effects.

research High-risk cutaneous squamous cell carcinoma in a Japanese allogeneic bone marrow transplant recipient on long-term voriconazole

2 citations , May 2017 in “The Journal of Dermatology”

This case report describes a Japanese bone marrow transplant recipient who developed a high-risk cutaneous squamous cell carcinoma on the scalp, potentially linked to long-term voriconazole use.