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GlossaryVoriconazole

antifungal drug treating serious fungal infections

Voriconazole is an antifungal medication used to treat serious fungal infections, such as aspergillosis and candidiasis. It works by inhibiting the growth of fungi, making it effective for patients with weakened immune systems. For professionals, it's important to note that Voriconazole is a triazole antifungal that inhibits the fungal cytochrome P450 enzyme 14α-demethylase, crucial for ergosterol synthesis in fungal cell membranes.

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research Adverse Effects of Voriconazole: Over a Decade of Use

100 citations, September 2016 in “Clinical transplantation/Clinical transplantation.”

Voriconazole can cause serious side effects, especially in long-term use.

research High-Risk Cutaneous Squamous Cell Carcinoma in a Japanese Allogeneic Bone Marrow Transplant Recipient on Long-Term Voriconazole

2 citations, May 2017 in “The Journal of Dermatology”

A Japanese bone marrow transplant patient developed a rare skin cancer possibly linked to long-term use of the medication voriconazole.

research Methotrexate, Tacrolimus, Voriconazole: High-Risk Cutaneous Squamous Cell Carcinoma in a 65-Year-Old Man

June 2018 in “Reactions Weekly”

A 65-year-old man developed a serious skin cancer linked to a drug he was taking for a fungal infection after a bone marrow transplant.

research Plain Language Summaries of Dermatology Studies

September 2015 in “British Journal of Dermatology”

Most clinicians follow discharge guidelines, many lupus patients don't use sunscreen regularly, dithranol is effective for psoriasis, biopsy methods should be based on lesion type, voriconazole may raise skin cancer risk, a new scale can help diagnose female hair loss early, and most melanomas may develop from existing moles.

research Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents

90 citations, May 2019 in “Drugs”

Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.

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