High-Risk Cutaneous Squamous Cell Carcinoma in a Japanese Allogeneic Bone Marrow Transplant Recipient on Long-Term Voriconazole

    May 2017 in “ The Journal of Dermatology ”
    William Ng, Akira Takahashi, Yusuke Muto, Naoya Yamazaki
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    TLDR A Japanese bone marrow transplant patient developed a rare skin cancer possibly linked to long-term use of the medication voriconazole.
    The document reported a rare instance of high-risk cutaneous squamous cell carcinoma (SCC) on the scalp of a 65-year-old Japanese male who had undergone a bone marrow transplant and was on long-term voriconazole treatment. The patient developed skin conditions indicative of SCC approximately 6.5 years after the transplant. A literature review suggested that such cases are uncommon in Asian hematopoietic stem cell transplant recipients, implying that voriconazole might have played a role in the development of SCC in this patient. This case was the first of its kind reported in an Asian patient, highlighting the potential link between voriconazole use and SCC development. The document underscored the importance of diligent skin monitoring for Asian patients on prolonged voriconazole therapy and the need to distinguish between skin issues caused by chronic graft-versus-host disease and those caused by voriconazole-induced phototoxicity.
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