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GlossaryPhototoxicity

skin reaction from sunlight exposure to certain chemicals

Phototoxicity refers to a skin reaction that occurs when certain chemicals or medications on the skin are exposed to sunlight, leading to damage. This can result in redness, inflammation, and sometimes blistering, similar to a severe sunburn. For professionals, it's important to note that phototoxic reactions are typically caused by the interaction of ultraviolet (UV) light with photosensitizing agents, which can be found in some topical treatments, systemic medications, or even certain plant compounds.

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research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations, October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

research Adverse Effects of Voriconazole: Over a Decade of Use

100 citations, September 2016 in “Clinical transplantation/Clinical transplantation.”

Voriconazole can cause serious side effects, especially in long-term use.

research Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents

90 citations, May 2019 in “Drugs”

Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.

Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

research Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

11 citations, August 2007 in “Bioorganic & Medicinal Chemistry Letters”

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

research Advances and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System

2 citations, August 2023 in “Pharmaceutics”

New skin disease treatments using TDDS are improving but face challenges like side effects and high costs.

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