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    Glossary Phototoxicity

    skin reaction from sunlight exposure to certain chemicals

    Phototoxicity refers to a skin reaction that occurs when certain chemicals or medications on the skin are exposed to sunlight, leading to damage. This can result in redness, inflammation, and sometimes blistering, similar to a severe sunburn. For professionals, it's important to note that phototoxic reactions are typically caused by the interaction of ultraviolet (UV) light with photosensitizing agents, which can be found in some topical treatments, systemic medications, or even certain plant compounds.

    Research 10 of 202

    1. Rational Design and Synthesis of 4-((1<i>R</i>,2<i>R</i>)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications Journal of medicinal chemistry · 2008 · 23 citations
    2. Characterization of Cutaneous Photoxicity Induced by Topical Alpha-Terthienyl and Ultraviolet A Radiation Journal of Investigative Dermatology · 1986 · 22 citations
    3. Adverse effects of voriconazole: Over a decade of use 2016 · 100 citations
    4. Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents Drugs · 2019 · 90 citations
    5. The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells Pharmaceuticals · 2021 · 48 citations
    6. Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 11 citations
    7. Human Dermal Safety Studies with Eflornithine HCl 13.9% Cream (Vaniqa™), a Novel Treatment for Excessive Facial Hair Current Medical Research and Opinion · 2000 · 3 citations
    8. Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System Pharmaceutics · 2023 · 2 citations
    9. High-risk cutaneous squamous cell carcinoma in a Japanese allogeneic bone marrow transplant recipient on long-term voriconazole The Journal of Dermatology · 2017 · 2 citations
    10. Systemic Antifungals Springer eBooks · 2018
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