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research Characterization of Xenobiotic Metabolizing Enzymes of a Reconstructed Human Epidermal Model from Adult Hair Follicles

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

research Co-Drug Strategy for Promoting Skin Targeting and Minimizing the Transdermal Diffusion of Hydroquinone and Tranexamic Acid

21 citations , September 2013 in “Current medicinal chemistry”

HAC and BAC improve skin targeting and reduce diffusion without causing irritation.

research Impact of Ester Promoieties on Transdermal Delivery of Ketorolac

10 citations , January 2014 in “Journal of Pharmaceutical Sciences”

Balancing lipophilicity and solubility is key for effective and safe ketorolac prodrugs.

research Activity of Steroid 4 and Derivatives 4a–4f as Inhibitors of the Enzyme 5α-Reductase Type 1

3 citations , June 2018 in “Bioorganic & medicinal chemistry”

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

research Fesoterodine: Pharmacological Properties and Clinical Implications

5 citations , May 2018 in “European journal of pharmacology”

Fesoterodine is effective and safe for elderly patients with overactive bladder.

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community PP405 Identity Research

UmbrellaLabsResearch in Research 292 upvotes 7 months ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community (30M) 3 years Fin and 10 months min

in Progress Pictures 307 upvotes 1 year ago

A user shared their progress using 1.25g finasteride daily for 3 years and 5g oral minoxidil for 10 months, reporting positive results. They seek advice on further improving their hairline, with no significant side effects mentioned.