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This review highlights the potential benefits of spironolactone in dermatology, particularly for female acne, supporting its safety over long-term use without extensive testing, but presents no new clinical results.

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

This study found that co-drugs synthesized from hydroquinone and tranexamic acid improved skin targeting and deposition, with reduced irritation and enhanced efficacy for treating hyperpigmentation.

In this study, the reconstructed skin epidermal model derived from hair follicles showed gene expression and enzyme functionality consistent with native human skin, suggesting its viability for studying skin metabolism and potential toxicity of dermo-cosmetic ingredients.

This study explored the potential of using isoenzyme detection after electrophoresis to characterize human hair, though no new clinical results are reported.

This study found that specific enzymes could be detected in fresh hair sheath cells, with most remaining detectable in older cells, except for Adenylate kinase and Esterase D.

In this study, researchers developed enzymatic methods to isolate hair cuticle cells and remove the hair cuticle layer, finding that the harvested cuticle cells are thermally more stable and contain different structural proteins compared to descaled hair fibers.

This study found that treating dogs with benign prostatic hyperplasia using osaterone acetate reduced prostatic volume and increased diffusion times of an ultrasound contrast agent, suggesting effective treatment and potential for CEUS monitoring.

This study found that combining prodigiosin and essential oil from Thuja orientalis leaves showed a synergistic effect against the 3rd larva stage of Cx. pipiens, significantly reducing acetylcholine esterase activity and altering midgut pH, compared to untreated larvae.

In this study, researchers identified several active metabolites in Eclipta alba, demonstrated strong interaction with Alzheimer's disease proteins, and found that 28 days of treatment improved memory without significant toxicity in rats, suggesting potential pathways for treating Alzheimer's.

This article reviews the role of enzymatic processes in drug and toxin metabolism, emphasizing their impact on solubility and elimination, without presenting new clinical findings.

This study reports that C3H/HeJ mice and DEBR rats serve as effective models for screening potential treatments for human alopecia areata, despite certain challenges in predictability and cost.

Minoxidil lowers blood pressure effectively but may cause unwanted hair growth and other side effects.

This study reported that new drugs, despite lower specificity compared to certain immunobiological therapies, are effective across various challenging dermatological diseases, such as psoriasis, psoriatic arthritis, atopic dermatitis, alopecia areata, and vitiligo.

Malnutrition can cause unusual eyelash growth and hair loss.

This study found that a 1% concentration of thyme oil was more effective at killing Demodex mites in vitro than higher concentrations of tea tree and sage oils, suggesting thyme oil may have therapeutic potential for ocular demodicosis.

This case report details the diagnosis and management of argininosuccinate lyase deficiency in an infant, emphasizing initial symptoms, treatment strategies, and subsequent liver transplant leading to recovery.

This article reviews the role of factor Xa inhibitors like Rivaroxaban and suggests they may eventually replace vitamin K antagonists, but their side effects require further clarification.

Treatment with dapsone, topical corticosteroids, and antibiotics improved the man's skin conditions.

This review summarizes the use of chlormadinone acetate for hormone replacement therapy and contraception, highlighting its anti-androgenic effects, contraceptive efficacy, and clinical tolerability, without offering new clinical results.

This study demonstrated that using a mass spectrometry imaging technique, researchers were able to visualize the incorporation of argan, avocado, and coconut oils into hair fibers, suggesting their potential in cosmetic and alopecia treatments by confirming oil absorption and fiber modification.

Hormonal contraceptives are effective for teens but require careful consideration of side effects and individual health.

This article reviews the potential clinical use of anabolic steroids in treating muscle loss from chronic diseases and aging and highlights both the benefits and risks of these substances in sports.

This review discusses recent advances in surface modification and endothelialization of biomaterials for vascular grafts, highlighting promising methods like gene engineering and targeting ligand immobilization to improve clinical outcomes.

This review discusses various strategies to enhance drug delivery through the skin barrier, highlighting liposomes as promising carriers for increased dermal concentrations in topical therapies, but reports no new research results.

This review compares animal and human skin characteristics in in vitro permeation studies but reports no new results, highlighting variations and the need for better model correlations.

This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.

This study suggests that while hair analysis using GC-MS is a sensitive method for detecting cocaine ingestion, it may not reliably indicate the amount, timing, or duration of drug use due to interindividual variability and multiple incorporation mechanisms.

This chapter reviews the complexity of hair and wool follicle formation, emphasizing the importance of cytological studies to understand the relationship between cellular components.

This review discusses recent advances in monophosphate prodrug strategies for HCV drug discovery, aiming to enhance oral absorption and stability, and reports no new clinical results.