38 citations
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June 2018 in “Archives of Toxicology” This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.
November 2022 in “Journal of Investigative Dermatology” This study found that Cyclosporin A may prolong the anagen phase of hair growth in cultured dermal papilla cells by decreasing TGF-β2 expression, similar to its mechanism in immunosuppression.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, the reconstructed skin epidermal model derived from hair follicles showed gene expression and enzyme functionality consistent with native human skin, suggesting its viability for studying skin metabolism and potential toxicity of dermo-cosmetic ingredients.