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research Characterization of Xenobiotic Metabolizing Enzymes of a Reconstructed Human Epidermal Model from Adult Hair Follicles

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

research Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models

38 citations, June 2018 in “Archives of Toxicology”

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

research Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

November 2020 in “Elsevier eBooks”

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

research Teriflunomide in Patients with Relapsing-Remitting Forms of Multiple Sclerosis

29 citations, January 2016 in “CNS drugs”

Teriflunomide is effective and generally safe for treating relapsing-remitting multiple sclerosis.

research High-Resolution Mass Spectrometric Investigation of the Phase I and II Metabolites of Finasteride in Pig Plasma, Urine, and Bile

2 citations, December 2013 in “Xenobiotica”

Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.

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community Oral Minoxidil and Grapefruit Juice

in Research/Science 96 upvotes 1 year ago

The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

community 7 months - 7 months oral dutasteride 0.5mg, 5 months oral minoxidil 12.5mg - 34 year old male

in Progress Pictures 82 upvotes 1 year ago

Hair loss progress and treatments, specifically oral dutasteride and oral minoxidil.

community This is lagunaboy and I have fully recovered from PFS

in Finasteride/Dutasteride 5 upvotes 2 years ago

The user recovered from Post-Finasteride Syndrome (PFS) using a specific hormone protocol after trying finasteride and dutasteride. They now help others with PFS by reviewing blood work and offering personalized advice.

community Perez Hilton Had 3 Transplants.. Yet Losing Hair.. Someone Explain?

in Transplants 71 upvotes 1 year ago

The conversation discusses Perez Hilton's hair loss despite having three hair transplants. Participants suggest that hair loss can continue after a transplant if maintenance treatments like finasteride and minoxidil are not used, and that transplanted hair can still be susceptible to loss.

community Possible explanation of why Dutasteride seems to be worse for some people’s hair.

in Treatment 47 upvotes 1 year ago

The conclusion of the conversation is that some individuals may experience a condition called reactionary hypergonadism when taking dutasteride for hair loss. This condition can lead to an increase in testosterone levels, which may worsen hair loss instead of improving it.

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