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This research highlights the use of 3D human skin model reconstructs as a promising method to study human skin biology, showing that these models replicate natural melanocyte and melanoma behaviors accurately.

This review discusses the development and findings of 3D human skin models for studying melanocyte homeostasis and melanoma progression but reports no new clinical results.

This study established that a human epidermal model can be utilized to assess 5alpha-reductase activity and evaluate enzyme modulators, such as finasteride, for dermatological applications.

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

This study demonstrates that incorporating human neopapilla into reconstructed human skin can initiate hair follicle morphogenesis by stimulating epidermal invagination and maintaining follicle-inductive properties in vitro.