The Three-Dimensional Human Skin Reconstruct Model: A Tool to Study Normal Skin and Melanoma Progression

    Ling Li, Mizuho Fukunaga‐Kalabis, Meenhard Herlyn
    TLDR 3D human skin models better mimic real skin and melanoma progression than 2D or mouse models.
    The three-dimensional human skin reconstruct model was developed to mimic the architecture and composition of human skin, providing a valuable tool for studying normal skin functions, melanoma progression, and the behavior of dermal stem cells. This model allowed researchers to investigate melanocyte physiology and the progression of melanoma in a controlled environment. Additionally, it served as a preclinical tool for assessing the efficacy of drugs, offering insights into potential treatments for skin-related conditions.
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