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Glossary Genomic Instability

increased tendency of DNA to acquire mutations

Genomic instability refers to an increased tendency of an organism's DNA to acquire mutations, which can lead to various genetic disorders, including cancer. For a layperson, it's like having a book where the words and sentences keep changing, making it hard to understand the original story. For professionals, it involves mechanisms such as DNA replication errors, defective DNA repair, and chromosomal rearrangements.

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Research

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research Comprehensive Genomic Profiling of Cutaneous Adnexal Carcinomas: A Genomic Landscape Study

March 2026 in “Dermatopathology”

This study found that sebaceous gland-derived cutaneous adnexal carcinomas exhibited the highest frequency of genomic alterations compared to other tumor types.

research Lamins in development, tissue maintenance and stress

64 citations , November 2012 in “EMBO reports”

This review discusses the role of lamins in development, tissue maintenance, and stress response, and does not report new experimental findings.

research Removing all obstacles: A critical role for p53 in promoting tissue renewal

30 citations , April 2010 in “Cell Cycle”

This review discusses how the p53 tumor suppressor gene helps maintain adult tissue homeostasis by promoting the removal of DNA-damaged cells, with implications for treating age-related diseases and p53-deficient cancers; it reports no new results.

research Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway

10 citations , October 2018 in “Journal of molecular and cellular cardiology/Journal of Molecular and Cellular Cardiology”

This study identified NM_026333 as a potential anti-aging gene that, when induced, may alleviate proton-induced aging symptoms in CF6-overexpressing and high salt-fed mice.

research Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells

5 citations , January 2021 in “iScience”

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

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community Genomic Sequencing for Hair Loss

in Research/Science 156 upvotes 6 months ago

Hair loss treatments like Minoxidil, finasteride, and potential mRNA therapies are discussed. There is skepticism about targeting specific genes due to the complex genetic nature of hair loss.

community Rhamnose-Mediated Modulation of Hair Follicle Growth: Insights from Chemical Genomics

in Research 47 upvotes 1 year ago

Rhamnose may promote hair growth and pigmentation, suggesting it as a potential hair loss treatment. The conversation discusses its potential alongside known treatments like Minoxidil, finasteride, and RU58841.

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