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    Glossary Genomic Instability

    increased tendency of DNA to acquire mutations

    Genomic instability refers to an increased tendency of an organism's DNA to acquire mutations, which can lead to various genetic disorders, including cancer. For a layperson, it's like having a book where the words and sentences keep changing, making it hard to understand the original story. For professionals, it involves mechanisms such as DNA replication errors, defective DNA repair, and chromosomal rearrangements.

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    1. Comprehensive Genomic Profiling of Cutaneous Adnexal Carcinomas: A Genomic Landscape Study Dermatopathology · 2026
    2. Lamins in development, tissue maintenance and stress EMBO reports · 2012 · 64 citations
    3. Removing all obstacles: A critical role for p53 in promoting tissue renewal Cell Cycle · 2010 · 30 citations
    4. Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway 2018 · 10 citations
    5. Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells iScience · 2021 · 5 citations
    6. Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders International Journal of Molecular Sciences · 2024
    7. Booby Trap: Cancer gene spurs production of DNA-assaulting chemicals that alert and defuse rescue molecule (Cancer; Oxidative damage) Science of aging knowledge environment · 2002
    8. Investigating the mechanisms underlying age-related dysfunctions in skin and hair follicle regeneration 2020
    9. Next generation human skin constructs as advanced tools for drug development Experimental Biology and Medicine · 2017 · 69 citations
    10. Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids Nature Cell Biology · 2021 · 36 citations
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    Community 1 of 2

    1. Genomic Sequencing for Hair Loss Reddit · 27 Mar 2026
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