Lamins in Development, Tissue Maintenance, and Stress

The review discussed the critical roles of lamins in development, tissue maintenance, and stress response, emphasizing their importance in providing mechanical stability, organizing chromatin, and regulating nuclear functions. It highlighted distinct roles for A- and B-type lamins, with B-type essential for cell survival and organ development, and A-type crucial for osteoblastogenesis and muscle integrity. Mutations in lamin genes caused various diseases, such as EDMD and HGPS, leading to muscle integrity issues, impaired DNA damage response, and premature aging. The study underscored the complexity of laminopathies and the need for further research to understand the specific contributions of different mechanisms to disease phenotypes. Additionally, the loss of LMNA was linked to telomere mislocalization, shortening, and genomic instability, contributing to increased senescence.