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    Glossary Genomic Instability

    increased tendency of DNA to acquire mutations

    Genomic instability refers to an increased tendency of an organism's DNA to acquire mutations, which can lead to various genetic disorders, including cancer. For a layperson, it's like having a book where the words and sentences keep changing, making it hard to understand the original story. For professionals, it involves mechanisms such as DNA replication errors, defective DNA repair, and chromosomal rearrangements.

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    Research 30 of 1000+

    1. Comprehensive Genomic Profiling of Cutaneous Adnexal Carcinomas: A Genomic Landscape Study Dermatopathology · 2026
    2. Lamins in development, tissue maintenance and stress EMBO reports · 2012 · 64 citations
    3. Removing all obstacles: A critical role for p53 in promoting tissue renewal Cell Cycle · 2010 · 30 citations
    4. Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway 2018 · 10 citations
    5. Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells iScience · 2021 · 5 citations
    6. Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders International Journal of Molecular Sciences · 2024
    7. Booby Trap: Cancer gene spurs production of DNA-assaulting chemicals that alert and defuse rescue molecule (Cancer; Oxidative damage) Science of aging knowledge environment · 2002
    8. Investigating the mechanisms underlying age-related dysfunctions in skin and hair follicle regeneration 2020
    9. Next generation human skin constructs as advanced tools for drug development Experimental Biology and Medicine · 2017 · 69 citations
    10. Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids Nature Cell Biology · 2021 · 36 citations
    11. Acute sensitivity of the oral mucosa to oncogenic <i>K‐ras</i> Journal of pathology · 2011 · 12 citations
    12. Adrenal Cortex Tumors and Hyperplasias InTech eBooks · 2011 · 2 citations
    13. Gene Editing Technologies in Aesthetic Dermatology—Mechanisms, Emerging Applications, and Patient Safety Paradigms 2025
    14. Decision letter: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ 2016
    15. Molecular mechanisms of viral oncogenesis in humans Nature Reviews Microbiology · 2018 · 141 citations
    16. Precision therapeutics in non-scarring alopecia: a systemic genomic and pathway-based framework for targeted interventions ADMET & DMPK · 2025
    17. Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D Molecular Endocrinology · 2002 · 277 citations
    18. A State-of-the-Art Overview on (Epi)Genomics and Personalized Skin Rejuvenating Strategies Pharmaceutics · 2025
    19. The Potential Relevance of the Microbiome to Hair Physiology and Regeneration: The Emerging Role of Metagenomics Biomedicines · 2021 · 11 citations
    20. Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Developmental Dynamics · 2015 · 19 citations
    21. The Genomic Variation in Textured Hair: Implications in Developing a Holistic Hair Care Routine Cosmetics · 2024
    22. The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia International Journal of Molecular Sciences · 2024
    23. Identification of compound heterozygous mutations in <i>AP1B1</i> leading to the newly described recessive keratitis–ichthyosis–deafness (KIDAR) syndrome British Journal of Dermatology · 2021 · 11 citations
    24. A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia 2020 · 2 citations
    25. Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation The EMBO Journal · 2016 · 29 citations
    26. Genome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses Cancer Research Communications · 2024 · 7 citations
    27. Single-Cell Omics Advances in Understanding Tissue Development and Complex Trait Formation in Sheep and Goats Animals · 2026
    28. A symphony of signals: the intricate role of lncRNAs in dermatological disorders Clinical and Experimental Medicine · 2025 · 1 citations
    29. Age-associated inflammation inhibits epidermal stem cell function Genes & development · 2012 · 144 citations
    30. Microarray analysis reveals distinct RNA expression profiles in endothelial progenitor cells exposed to pro-inflammatory environment or oxidized LDL Vascular Pharmacology · 2015