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Research

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Deciphering the Function of Canonical Wnt Signals in Development and Disease: Conditional Loss- and Gain-of-Function Mutations of β-Catenin in Mice

research Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of β-catenin in mice

556 citations , September 2008 in “Genes & Development”

This review summarizes how genetic studies using conditional β-catenin loss- and gain-of-function mice have advanced understanding of canonical Wnt signaling's role in embryonic development, adult stem cell maintenance, and cancer modeling.

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

This study found that castration-resistant prostate cancers resistant to CYP17A1 inhibitors may still depend on steroids and could respond to therapies targeting de novo intratumoral steroid synthesis.

research Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

293 citations , September 2004 in “Development”

This study found that WNT signaling is essential for the initiation of mammary gland morphogenesis in embryonic mice, promoting placode development and potentially playing a critical role in skin appendage formation.

research Skin Cell Heterogeneity in Development, Wound Healing, and Cancer

211 citations , May 2018 in “Trends in cell biology”

This review explores recent insights into the diverse cell populations involved in skin development, homeostasis, wound healing, and cancer progression but reports no new results.

research Cantú Syndrome Is Caused by Mutations in ABCC9

148 citations , May 2012 in “The American Journal of Human Genetics”

This study identified heterozygous mutations in the ABCC9 gene as the genetic basis of Cantú syndrome, suggesting the syndrome as a new member of potassium channelopathies.

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Community Join

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community Can I alternate oral and topical minoxidil?

2 upvotes 1 week ago

Alternating between oral and topical minoxidil is considered, with concerns about staining bed sheets. Oral minoxidil may cause more body hair but is less messy than topical.

community Can plaques and build up on the scalp potentially stop new hairs from growing there?

4 upvotes 1 week ago

Scalp build-up may affect hair growth, but experiences vary. Treatments mentioned include ketoconazole, clobetasol, and Head & Shoulders shampoo.

community Can a transplant fill my head?

6 upvotes 3 weeks ago

A 22-year-old is considering a hair transplant to address diffuse thinning and is currently using oral finasteride and minoxidil, with plans to switch to oral dutasteride. They are debating between one or two procedures and are seeking advice on graft numbers and additional treatments like oils and micro-needling.

community Can I start Topical Finasteride and Minoxidil without Doctor's prescription

in Finasteride/Dutasteride 4 upvotes 3 weeks ago

The conversation is about starting topical finasteride and minoxidil for hair loss without a doctor's prescription. The user discusses genetic predisposition to hair loss and mentions lifestyle impacts.

community Can you see any progress in 2.5 months (on topical + 1 mg Finasteride)

in Progress Pictures 4 upvotes 1 month ago

The user is using topical Minoxidil 5% and 1 mg Finasteride for hair loss and believes there is progress in 2.5 months, though opinions on progress vary. Some users see modest improvement, while others suggest better photo consistency for clearer assessment.

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Learn

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learn Dutasteride

Can I use dutasteride without a prescription? All about its sale and regulations. Dutasteride requires a prescription and cannot be used without medical supervision.

learn Ketoconazole

Can I use ketoconazole shampoo if I am pregnant or breastfeeding? Consult your doctor before using ketoconazole shampoo while pregnant or breastfeeding.
Can ketoconazole make hair loss worse before it makes it better? Ketoconazole may cause temporary hair shedding before potential improvement in hair growth.

learn Rosemary

Can rosemary prevent hair loss before it starts? Rosemary may help improve scalp health, but evidence for preventing hair loss is limited.

learn Melatonin

Can melatonin cause side effects on the skin or hair? Melatonin may cause hair loss or thinning in some users, but evidence is limited.

Clinics

6 / 97 results

All 97 clinic results →