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GlossaryPolymeric Micelles

tiny, self-assembling spheres that deliver drugs in the body

Polymeric micelles are tiny, spherical structures formed when certain types of polymers (large molecules made up of repeating units) self-assemble in water. They have a hydrophobic (water-repelling) core and a hydrophilic (water-attracting) shell, making them useful for delivering drugs or other substances in the body, as they can encapsulate hydrophobic drugs in their core and transport them through the bloodstream.

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research Polymeric Micelle Nanocarriers for the Cutaneous Delivery of Tacrolimus: A Targeted Approach for the Treatment of Psoriasis

159 citations , July 2014 in “Molecular pharmaceutics”

New micelle nanocarriers deliver Tacrolimus more effectively to skin layers for psoriasis treatment than the current Protopic ointment.

Preparation and In Vitro Evaluation of Protective Effects of Silibinin-Loaded Polymeric Micelles on Human Hair Against UV-B Radiation

research Preparation and In Vitro Evaluation of Protective Effects of Silibinin-Loaded Polymeric Micelles on Human Hair Against UV-B Radiation

January 2024 in “Journal of cosmetic dermatology”

Silibinin-loaded micelles significantly protect hair from UV-B damage.

Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

research Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

9 citations , June 2021 in “International Journal of Pharmaceutics”

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

research Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle

59 citations , January 2015 in “Nanoscale”

The new micelle formulation delivers acne treatment more effectively and safely than current gels.

research Novel Micelle Formulations to Increase Cutaneous Bioavailability of Azole Antifungals

109 citations , March 2011 in “Journal of controlled release”

New micelle solutions greatly improve skin delivery of certain antifungal drugs.

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community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 3 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 23 upvotes 4 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community Me on 5 milligrams of Finasteride, off label oral Min, a $3000 red light therapy cap, experimental Russian drugs, and three Turkish hair transplants watching a 60 year old homeless man with a perfect hairline smoke crack

in Satire 2726 upvotes 11 months ago

The conversation humorously discusses the unfairness of hair loss, highlighting various treatments like finasteride, minoxidil, red light therapy, and experimental drugs, while contrasting with people who have great hair despite unhealthy lifestyles. The original poster mentions experiencing side effects from switching to oral finasteride.

community Hairloss progress photos: Dp you think this is a good position?

in Is this regrowth? 39 upvotes 9 months ago

A 33-year-old experienced hairline improvement using finasteride and minoxidil, later stopping minoxidil while continuing ketoconazole shampoo. Initial side effects included shedding, reduced libido, and anxiety, but these resolved, leading to a full hairline recovery.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 14 upvotes 5 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

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