Solubility Preformulation Screening of Minoxidil in Different Natural Oils Using Experimental and Computational Approaches

December 2025 in “ Processes ”

Khothatso Mapule Annah Motloung, Bwalya Angel Witika, Pedzisai Anotida Makoni

minoxidil Hansen solubility parameter shea butter stearic acid rosemary oil drug-lipid solubility parameter Relative Energy Difference lipidic carriers Rogaine

TLDR Minoxidil dissolves best in shea butter, stearic acid, and rosemary oil, which may improve hair growth treatments.

This study explores the use of Hansen solubility parameter (HSP) predictions to determine the solubility of minoxidil in natural oils known for hair growth activity. The research employed a dual-tiered screening strategy combining HSP predictions with experimental validation. Results showed that minoxidil had the highest solubility in shea butter, stearic acid, and rosemary oil. Stearic acid and rosemary oil also had the lowest drug-lipid solubility parameter differences and Relative Energy Difference values, supporting the experimental findings. These results suggest that selecting natural oils based on HSP data can enhance minoxidil solubility, potentially improving drug loading and encapsulation efficiency in lipidic carriers, with implications for hair growth treatments and reduced formulation costs.

View this study on mdpi.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community 2 years after using finasteride

in Update 1203 upvotes 3 years ago

A user's two-year journey of using finasteride and minoxidil to treat hair loss, with other users providing advice, tips, and encouragement.

community Table of the relationship between physical exercise and the regeneration of the deminiaturized hair follicle

in Research/Science 46 upvotes 1 year ago

Exercise, especially leg workouts, combined with finasteride and minoxidil, may enhance hair regrowth. Cold exposure, like cold showers, might further boost results.

community My hair after 3 steroid cycles

in Progress Pictures 27 upvotes 1 year ago

A user shared their hair progress after three steroid cycles, using 5% minoxidil and 100mg RU58841 daily. They are considering a hair transplant due to paranoia about shedding.

community pyrilutamide any results so far?

in Treatment 45 upvotes 3 years ago

The hair loss treatment Pyrilutamide and whether it has had any results for users. Martinsahara is planning to buy some soon.

community How do you even get time to “enjoy” your hair while on minoxidil?

in Minoxidil 299 upvotes 1 day ago

Minoxidil is often applied once or twice daily for hair growth, but many find it inconvenient and switch to once daily or oral minoxidil for ease. Some users combine it with finasteride for better results, despite potential side effects.