Colistin Adorned Topical Nanoemulsion Gel Formulation for Enhanced Antimicrobial Activity

    September 2025 in “ Scientific Reports ”
    Falaq Ijaz, Bushra Nasir, Sheikh Abdur Rashid, Faiza Naseem, Aamir Jalil, Aayesha Riaz, Jalifah Latip, Khalid J. Alzahrani, Khalaf F. Alsharif, Abul Kalam Azad
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    Studysummary This study reported that a colistin sulfate-loaded nanoemulgel showed improved antimicrobial activity and skin permeability compared to a CS solution, suggesting a potential new approach for treating severe infections caused by multidrug-resistant bacteria.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The study developed a colistin sulfate-loaded nanoemulgel (CS-NEG) to enhance antimicrobial activity against multidrug-resistant bacteria in severe skin infections. The formulation process involved creating a nanoemulsion (NE) using specific oils and surfactants, which was then converted into a gel using Carbopol 940. The CS-NEG demonstrated favorable physico-chemical properties, including appropriate pH, high viscosity, and excellent spreadability. It achieved a cumulative drug release of 73.6% to 84.31% over 24 hours and showed improved skin permeability and antimicrobial activity, with a zone of inhibition of 21.23 mm, compared to the CS solution. These results indicate that the CS-NEG formulation is a promising strategy for treating complex bacterial infections.
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