Oral Administration of Lactilactobacillus Curvatus LB-P9 Promotes Hair Regeneration in Mice

The study investigated the effects of Lactilactobacillus curvatus LB-P9 on hair regeneration in mice. Oral administration of LB-P9, in both low and high doses, significantly accelerated hair regrowth and increased hair thickness compared to a control group. This was associated with elevated levels of hair growth factors (VEGF, FGF-7, IGF-1), increased β-catenin, and a higher number of hair follicle stem cells in the treated mice. The findings suggest that LB-P9 promotes hair regeneration by enhancing dermal papilla cell proliferation and stimulating hair growth factor production.