Uncovering the Complex Relationship Between Balding, Testosterone, and Skin Cancers in Men

October 2023 in “ Nature Communications ”

Jue‐Sheng Ong, Mathias Seviiri, Jean Claude Dusingize, Yeda Wu, Xikun Han, Jianxin Shi, Catherine M. Olsen, Rachel Ε. Neale, John F. Thompson, Robyn P.M. Saw, Kerwin F. Shannon, Graham J. Mann, Nicholas G. Martin, Sarah E. Medland, Scott D. Gordon, Richard A. Scolyer, Georgina V. Long, Mark M. Iles, Maria Teresa Landi, David C. Whiteman, Stuart MacGregor, Matthew H. Law

male-pattern baldness testosterone skin cancers Mendelian randomization cutaneous melanoma keratinocyte cancers genetic variations pigmentation pathways squamous cell carcinoma melanoma UV exposure MPB UV

Studysummary In this study, male-pattern baldness was strongly associated with a higher risk of keratinocyte cancers, particularly squamous cell carcinoma and melanoma, likely due to increased sun exposure on the scalp rather than androgen levels.

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