Identification of Beta-Sitosterol and Stigmasterol as Possible Inhibitors of 5 Alpha-Reductase 1: An In-Silico Study

    January 2022 in “ Precision medicine and clinical omics ”
    Pardis Zamani, Omid Mokhtari, Fariba Dehghanian
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    TLDR Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.
    The in-silico study investigated potential inhibitors of the 5 Alpha-Reductase 1 (5AR1) enzyme, a key factor in androgenetic alopecia (AGA) or hair loss. Using homology modeling and molecular docking approaches, the study found that two natural compounds, beta-sitosterol and stigmasterol, isolated from the plant Serenoa repens, could inhibit the regular activity of 5AR1. These compounds showed strong docking affinity of -10.7 and -10.1 kcal/mol, respectively, indicating strong interactions with 5AR1. The study also identified 11 amino acid residues involved in the majority of inhibitor and 5AR1 interaction sites, suggesting these residues are essential to inhibit this protein. These findings suggest that beta-sitosterol and stigmasterol could potentially be used as safe and novel AGA medicines for hair restoration.
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      community A battle won?

       7 upvotes 9 years ago
      The user tried various treatments for hair loss, including finasteride, vitamins, Saw Palmetto, beta sitosterol, pumpkin oil, borage oil, stinging nettle, and emu oil. They recently noticed tiny black hairs, suggesting some improvement.

      community (Topic) does saw palmetto actually work?

      in Chat  1 upvotes 6 months ago
      Saw palmetto can help reduce DHT levels and may work in combination with other supplements like beta sitosterol and pygume, but it's less effective than finasteride. Additional treatments like pumpkin seed extract, zinc, biotin, essential oils, scalp massages, and micro-needling can support hair health, but should not replace existing treatments like finasteride.

      community 5-Months Update: Minoxidil + Red Light Therapy + Lifestyle Changes

      in Progress Pictures  1007 upvotes 1 month ago
      The user reported positive hair regrowth after 5 months using Minoxidil, red light therapy, and lifestyle changes, including dietary improvements and stress reduction. They chose natural supplements like saw palmetto and beta-sitosterol over pharmaceutical DHT inhibitors like finasteride.

      community The ultimate Regimen for density and thick ess

      in Treatment  10 upvotes 6 months ago
      The regimen for hair loss includes topical finasteride, clascoterone, tretinoin, minoxidil, oral saw palmetto, beta-sitosterol, vitamin D, microneedling, and anti-fungal shampoo. Expected benefits are increased hair growth and density, with considerations for potential skin irritation and interactions between treatments.

      community My Experience and a Discourse on "DUPA"

      in Treatment  9 upvotes 10 months ago
      The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 6 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

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