In-Silico Screening of ATP-Competitive Inhibitory Activities of Phytochemicals Against Janus Kinase 3 and Its In-Vitro Evaluation

    April 2020 in “ ˜The œFASEB journal ”
    Ryun-Hee Kim, Taehwan Lim, Keum Taek Hwang
    TLDR Poncirin is a promising inhibitor of Janus Kinase 3, potentially better than tofacitinib.
    The study conducted an in-silico screening to identify phytochemicals with ATP-competitive inhibitory activities against Janus Kinase 3 (JAK3), followed by in-vitro evaluation of the identified compounds. The research aimed to find potential therapeutic agents for diseases involving JAK3, such as certain types of alopecia. The in-silico analysis identified several promising phytochemicals, which were then tested in-vitro to confirm their inhibitory effects on JAK3. The results showed that some of these compounds effectively inhibited JAK3 activity, suggesting their potential as treatments for conditions related to JAK3 dysregulation.
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